Impact of highly active antiretroviral therapy on organ‐specific manifestations of HIV‐1 infection
| Autor: | D Torre, R Martegani, Filippo Speranza |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Male
Tuberculosis HAART Exacerbation Uterine Cervical Neoplasms HIV Infections Disease Cervix Uteri Kidney Antiviral Agents Acquired immunodeficiency syndrome (AIDS) Immune reconstitution inflammatory syndrome Antiretroviral Therapy Highly Active medicine Humans Pharmacology (medical) organ manifestations Lung Original Research Skin AIDS-Related Opportunistic Infections business.industry Health Policy Incidence Pneumonia Pneumocystis virus diseases Brain Heart medicine.disease HIV infection Hodgkin Disease AIDS Gastrointestinal Tract Pneumonia Infectious Diseases Mycobacterium Avium Complex Lymphadenitis Liver Cryptococcosis Immunology HIV-1 Female business |
| Zdroj: | HIV Medicine |
| ISSN: | 1468-1293 1464-2662 |
| Popis: | In the last 10 years, interesting results have been reported concerning the impact of highly active antiretroviral therapy (HAART) on the changing pattern of organ-specific manifestations of HIV-1 infection. There has been a clear step-wise reduction in the incidence of several opportunistic infections (OIs), particularly Pneumocystis carinii pneumonia, whereas a nonsignificant reduction in incidence has been observed for other organ-specific diseases, including invasive cervical cancer and Hodgkin disease. In addition, several organ-specific manifestations, including HIV-associated nephropathy, wasting syndrome and cardiomiopathy, are a direct consequence of damage by HIV-1, and so HAART may have a therapeutic effect in improving or preventing these manifestations. Finally, the introduction of HAART has seen the emergence of several complications, termed immune reconstitution inflammatory syndrome, which includes OIs such as cytomegalovirus vitritis, Mycobacterium avium complex lymphadenitis, paradoxical responses to treatment for tuberculosis, and exacerbation of cryptococcosis. Because not all HIV-1 organ-specific manifestations are decreasing in the HAART era, this review will analyse the influence of HAART on several organ-specific manifestations, and in particular OIs related to several organs, cerebral disorders and HIV-1-related neoplasia. |
| Databáze: | OpenAIRE |
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