Unique clinical characteristics, autoantibodies and medication use in Native American patients with systemic lupus erythematosus
| Autor: | John B. Harley, Adriana Rojas Villarraga, Daniel J. Wallace, Juan-Manuel Anaya, Michael H. Weisman, James N. Jarvis, Jonathon R Johnston, Carla J. Guthridge, Joseph M Kheir, Judith A. James, Joel M. Guthridge, Kathy L. Sivils, Melissa E. Munroe, Rebecka L. Bourn, Timothy Gross, Lucas J. Adams, Astrid Rasmussen |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Mycophenolate Mofetil Anti-nuclear antibody autoantibodies Immunofluorescence Hispanic Immunoglobulin G Antibody Autoantibody 0302 clinical medicine Antibody Specificity Photosensitivity immune system diseases Enzyme Linked Immunosorbent Assay Medicine Antinuclear Antibody African American European American skin and connective tissue diseases antinuclear antibodies (ANA) Immunoglobulin M Antibody systemic lupus erythematosus (SLE) Systemic lupus erythematosus Medical record Interstitial lung disease Cardiolipin Antibody General Medicine 3. Good health Race Difference American Indian Priority Journal Female Mouth Ulcer Hydroxychloroquine Human medicine.drug Adult Antibody Titer medicine.medical_specialty Anticuerpos Major Clinical Study Immunology Systemic Sclerosis Interstitial Lung Disease Systemic Lupus Erythematosus Article Precipitin 03 medical and health sciences Raynaud Phenomenon Internal medicine Double Stranded Dna Antibody Controlled Study Ethnic Difference 030203 arthritis & rheumatology business.industry Clinical Feature Lupus eritematoso medicine.disease Enfermedades Epidemiology and Outcomes Rheumatology Methotrexate Sjoegren Syndrome 030104 developmental biology Drug Use business |
| Zdroj: | Lupus Science & Medicine Manuel, F., Ugarte-Gil, G.J.P.-E., Alarcon, G.S., Epidemiology (2016) Systemic Lupus Erythematosus Repositorio EdocUR-U. Rosario Universidad del Rosario instacron:Universidad del Rosario |
| ISSN: | 2053-8790 |
| Popis: | Objective: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with varied morbidity and mortality. We assessed clinical presentations, autoantibody specificities and therapeutic interventions in Native American (NA) patients with SLE. Methods: Patients with SLE meeting 1997 American College of Rheumatology classification criteria (n=3148) were enrolled between 1992 and 2010 in the multiethnic, cross-sectional Lupus Family Registry and Repository. Clinical, demographic and therapeutic information were extracted from medical records using a standardised form and formalised training. Autoantibodies were assessed by indirect immunofluorescence (antinuclear antibodies (ANA) and antidouble-stranded DNA), precipitin (ENA) and ELISA (IgG and IgM anticardiolipins). Results: NA patients met SLE classification at a younger age (29.89±12.3 years) than European Americans (EA; 32.02±12.87, P=0.0157) and a similar age to African-Americans (AAs) and Hispanics (HIS). More NA patients had concurrent rheumatic diseases or symptoms, such as Raynaud's phenomenon, interstitial lung disease, Sjögren's syndrome and systemic sclerosis. Compared with EAs, NAs were more likely to have high-titre ANA (≥1:3240; P |
| Databáze: | OpenAIRE |
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