Desorption electrospray ionisation mass spectrometry: A rapid screening tool for veterinary drug preparations and forensic samples from hormone crime investigations
| Autor: | F.C. Claassen, Mirjam Nielen, T.A. van Beek, H. Hooijerink, M.C. van Engelen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Electrospray
Spectrometry Mass Electrospray Ionization residue analysis urine samples Mass spectrometry Biochemistry Analytical Chemistry injection sites Environmental Chemistry Animals ambient conditions Veterinary drug Sample preparation anabolic-steroids cocktails Quadrupole ion trap growth-promoting agents Spectroscopy BU Microbiological & Chemical Food Analysis Chemical ionization Chromatography Chemistry Forensic Sciences Organic Chemistry Veterinary Drugs Organische Chemie Hormones Substance Abuse Detection gas-chromatography Cattle Steroids Ion trap Gas chromatography Crime BU Microbiologische & Chemische Voedselanalyse |
| Zdroj: | Analytica Chimica Acta, 637(1-2), 92-100 Analytica Chimica Acta 637 (2009) 1-2 |
| ISSN: | 0003-2670 |
| Popis: | Hormone and veterinary drug screening and forensics can benefit from the recent developments in desorption electrospray ionisation (DESI) mass spectrometry (MS). In this work the feasibility of DESI application has been studied. Using a linear ion trap or quadrupole time-of-flight (TOF) MS instrument both full-scan and data-dependent collision-induced dissociation MS n spectra were acquired in seconds without sample preparation. Preliminary data are presented for the rapid screening of (pro)hormone supplement samples, an illegal steroid cocktail and forensic samples from veterinary drug investigations. The potential of this DESI approach is clearly demonstrated since compounds observed could be independently confirmed by liquid chromatography/TOFMS with accurate mass measurement, and/or proton nuclear magnetic resonance spectroscopy. Specific concerns related to false-positive and false-negative findings due to limitations in quantification and memory-effects are briefly discussed. It is envisaged that DESI will achieve a prominent role in hormone and veterinary drug analysis in the near future. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect