Prospective association between alcohol intake and hormone-dependent cancer risk: modulation by dietary fiber intake
| Autor: | Philippine Fassier, Pilar Galan, Mélanie Deschasaux, Paule Latino-Martel, Anne-Sophie Chhim, Laurent Zelek, Nathalie Druesne-Pecollo, Serge Hercberg, Lucie Duverger, Mathilde Touvier |
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| Přispěvatelé: | Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Paris 13 (UP13)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), French Ministry of Research and Higher Education (A-SC), Canceropole Ile-de-France, Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Hôpital avicenne, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Avicenne-Université Sorbonne Paris Nord, Hôpital Avicenne-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Sorbonne Paris Nord |
| Rok vydání: | 2015 |
| Předmět: |
Male
Oncology medicine.medical_treatment Medicine (miscellaneous) MESH: Alcohol Drinking/adverse effects MESH: Proportional Hazards Models Prostate cancer Risk Factors MESH: Risk Factors Prostate Sex Hormone-Binding Globulin MESH: Diet Records MESH: Testicular Neoplasms/epidemiology Prospective Studies Gonadal Steroid Hormones Prospective cohort study ComputingMilieux_MISCELLANEOUS Randomized Controlled Trials as Topic Ovarian Neoplasms MESH: Middle Aged Nutrition and Dietetics alcohol MESH: Ovarian Neoplasms/blood MESH: Follow-Up Studies Middle Aged dietary fiber prostate cancer Diet Records MESH: Dietary Fiber/administration & dosage 3. Good health medicine.anatomical_structure Female MESH: Breast Neoplasms/epidemiology prospective study Adult MESH: Prostatic Neoplasms/blood medicine.medical_specialty Alcohol Drinking MESH: Testicular Neoplasms/blood Breast Neoplasms [SDV.CAN]Life Sciences [q-bio]/Cancer breast cancer Breast cancer Testicular Neoplasms Internal medicine MESH: Endometrial Neoplasms/blood medicine Humans Proportional Hazards Models MESH: Humans business.industry Proportional hazards model MESH: Breast Neoplasms/blood Prostatic Neoplasms Cancer MESH: Adult MESH: Gonadal Steroid Hormones/blood medicine.disease hormone-dependent cancer MESH: Prostatic Neoplasms/epidemiology MESH: Male MESH: Prospective Studies Endometrial Neoplasms MESH: Sex Hormone-Binding Globulin/metabolism MESH: Ovarian Neoplasms/epidemiology Steroid hormone MESH: Randomized Controlled Trials as Topic MESH: Endometrial Neoplasms/epidemiology [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie business MESH: Female [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition Follow-Up Studies Hormone |
| Zdroj: | American Journal of Clinical Nutrition American Journal of Clinical Nutrition, American Society for Nutrition, 2015, 102 (1), pp.182-189. ⟨10.3945/ajcn.114.098418⟩ |
| ISSN: | 0002-9165 |
| DOI: | 10.3945/ajcn.114.098418 |
| Popis: | Background Alcohol intake is associated with increased circulating concentrations of sex hormones, which in turn may increase hormone-dependent cancer risk. This association may be modulated by dietary fiber intake, which has been shown to decrease steroid hormone bioavailability (decreased blood concentration and increased sex hormone-binding globulin concentration). However, this potential modulation has not been investigated in any prospective cohort. Objectives Our objectives were to study the relation between alcohol intake and the risk of hormone-dependent cancers (breast, prostate, ovarian, endometrial, and testicular) and to investigate whether dietary fiber intake modulated these associations. Design This prospective observational analysis included 3771 women and 2771 men who participated in the Supplementation en Vitamines et Mineraux Antioxydants study (1994-2007) and completed at least 6 valid 24-h dietary records during the first 2 y of follow-up. After a median follow-up of 12.1 y, 297 incident hormone-dependent cancer cases, including 158 breast and 123 prostate cancers, were diagnosed. Associations were tested via multivariate Cox proportional hazards models. Results Overall, alcohol intake was directly associated with the risk of hormone-dependent cancers (tertile 3 vs. tertile 1: HR: 1.36; 95% CI: 1.00, 1.84; P-trend = 0.02) and breast cancer (HR: 1.70; 95% CI: 1.11, 2.61; P-trend = 0.04) but not prostate cancer (P-trend = 0.3). In stratified analyses (by sex-specific median of dietary fiber intake), alcohol intake was directly associated with hormone-dependent cancer (tertile 3 vs. tertile 1: HR: 1.76; 95% CI: 1.10, 2.82; P-trend = 0.002), breast cancer (HR: 2.53; 95% CI: 1.30, 4.95; P-trend = 0.02), and prostate cancer (HR: 1.37; 95% CI: 0.65, 2.89; P-trend = 0.02) risk among individuals with low dietary fiber intake but not among their counterparts with higher dietary fiber intake (P-trend = 0.9, 0.8, and 0.6, respectively). The P-interaction between alcohol and dietary fiber intake was statistically significant for prostate cancer (P = 0.01) but not for overall hormone-dependent (P = 0.2) or breast (P = 0.9) cancer. Conclusion In line with mechanistic hypotheses and experimental data, this prospective study suggested that dietary fiber intake might modulate the association between alcohol intake and risk of hormone-dependent cancer. This trial was registered at clinicaltrials.gov as NCT00272428. |
| Databáze: | OpenAIRE |
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