Solid-phase synthesis of a library based on biphenyl-containing trypsin-like serine protease inhibitors

Autor:	Ramesh Kakarla, James C. Sutton, Shirong Zhu, Robert D. Hutchins, Samuel Gerritz, Bogumila Rachwal, Zheming Ruan, Daniel L. Cheney, Michael J. Sofia, Shuhao Shi
Rok vydání:	2009
Předmět:	Protein Conformation Stereochemistry Molecular Sequence Data Clinical Biochemistry Pharmaceutical Science Biochemistry Chemical synthesis Substrate Specificity Structure-Activity Relationship chemistry.chemical_compound Solid-phase synthesis Peptide Library Drug Discovery Serine medicine Protease Inhibitors Mast Cells Molecular Biology Serine protease Aspartic Acid biology Aryl Biphenyl Compounds Serine Endopeptidases Organic Chemistry HIV Protease Inhibitors Protease inhibitor (biology) chemistry Enzyme inhibitor biology.protein Molecular Medicine Trifluoromethanesulfonate Boronic acid medicine.drug
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 19:6477-6480
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2009.08.100
Popis:	The solid-phase synthesis of a library based on an unusual biphenyl-containing trypsin-like serine protease inhibitor is described. Key to this effort was the synthesis of a highly functionalized aryl boronic acid reagent which required the development of a novel and efficient method to convert a triflate to a pinacolboronate in large scale.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2287529f3595663e6f1ca28ba0600c https://doi.org/10.1016/j.bmcl.2009.08.100 Zobrazit plný text záznamu Full Text from ScienceDirect