Novel prophylactic and therapeutic vaccine against tuberculosis
| Autor: | Masaji Okada, Jasmin Burgos, Toshihiro Nakajima, Yasuko Nishida, Kyoko Takao, Hitoshi Nakatani, Noriko Kanamaru, Paul Saunderson, Makoto Matsumoto, Yoshikazu Inoue, Rodolfo M. Abalos, David N. McMurray, Mitsunori Sakatani, Yoko Kita, Esterlina V. Tan, Tetsuji Nagasawa, E.C. Dela Cruz, Shigeto Yoshida, Satomi Hashimoto, Chie Kishigami, Yasufumi Kaneda |
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| Rok vydání: | 2009 |
| Předmět: |
Tuberculosis
Chaperonins CD8 Antigens medicine.medical_treatment Virus DNA vaccination Mycobacterium tuberculosis Mice Immune system Bacterial Proteins Drug Resistance Multiple Bacterial Vaccines DNA Animals Medicine Tuberculosis Vaccines Lung General Veterinary General Immunology and Microbiology biology business.industry Vaccination Public Health Environmental and Occupational Health Chaperonin 60 Immunotherapy biology.organism_classification medicine.disease Interleukin-12 Virology Macaca fascicularis Infectious Diseases Immunology Interleukin 12 Molecular Medicine business |
| Zdroj: | Vaccine. 27:3267-3270 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2009.01.064 |
| Popis: | We have developed a novel tuberculosis (TB) vaccine; a combination of the DNA vaccines expressing mycobacterial heat shock protein 65 (HSP65) and interleukin 12 (IL-12) delivered by the hemagglutinating virus of Japan (HVJ)-envelope and -liposome (HSP65 + IL-12/HVJ). This vaccine provided therapeutic efficacy as well as remarkable protective efficacy via CD8 + T and CD4 + T cells in murine models compared with the saline controls, on the basis of CFU of number of multi-drug resistant TB (MDR-TB), and survival of extremely drug resistant TB (XDR-TB) challenged mice. Furthermore, we extended our studies to a cynomolgus monkey model, which is currently the best animal model of human tuberculosis. This vaccine exerted therapeutic efficacy (survival and immune responses) in the TB-infected monkeys. These data indicate that our novel DNA vaccine might be useful against Mycobacterium tuberculosis including XDR-TB and MDR-TB for human therapeutic clinical trials. |
| Databáze: | OpenAIRE |
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