Leukoencephalitis Associated with Selective Viral Replication in the Brain of a Pony with Experimental Chronic Equine Infectious Anemia Virus Infection
| Autor: | M. T. Long, J. L. Oaks, T. V. Baszler |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
0301 basic medicine
040301 veterinary sciences Anemia viruses Disease Biology Virus Replication Polymerase Chain Reaction Virus law.invention 0403 veterinary science Lesion Equine infectious anemia 03 medical and health sciences law biology.animal medicine Animals Horses In Situ Hybridization Polymerase chain reaction DNA Primers General Veterinary Pony Brain 04 agricultural and veterinary sciences medicine.disease biology.organism_classification Virology Leukoencephalitis Acute Hemorrhagic Equine Infectious Anemia 030104 developmental biology Viral replication Immunology Horse Diseases medicine.symptom Spleen Infectious Anemia Virus Equine |
| Zdroj: | Veterinary Pathology. 41:527-532 |
| ISSN: | 1544-2217 0300-9858 |
| Popis: | Neurologic disease occurs sporadically in horses infected with the equine infectious anemia virus (EIAV). This report describes a case of clinically severe neurologic disease in a pony experimentally infected with EIAV. This pony did not have fever or anemia, which are the characteristic clinical signs of disease. The histopathologic changes were characterized as lymphohistiocytic periventricular leukoencephalitis. Polymerase chain reaction and in situ hybridization data showed that the brain lesions were directly associated with viral replication and that high-level viral replication occurred selectively within the lesion and not in other tissues. These findings suggest that EIAV-associated neurologic disease is the direct result of viral replication. |
| Databáze: | OpenAIRE |
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