Autoantibodies in male homosexuals and HIV infection
| Autor: | Handzel Zt, Zvi Bentwich, Yehuda Shoenfeld, R. Burstein, Ami Schattner, Shmuel Argov |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Anti-nuclear antibody Immunology DNA Single-Stranded Enzyme-Linked Immunosorbent Assay HIV Infections Biology Autoantigens Virus Serology Acquired immunodeficiency syndrome (AIDS) Antigen AIDS-Related Complex Immunopathology HIV Seropositivity medicine Immunology and Allergy Humans Autoantibodies Acquired Immunodeficiency Syndrome Autoantibody virus diseases DNA Homosexuality medicine.disease Virology Viral disease |
| Zdroj: | Immunology letters. 30(1) |
| ISSN: | 0165-2478 |
| Popis: | We have used ELISA to study the frequency of autoantibodies to several antigens in the serum of 17 male homosexuals (MHS) negative for HIV (HIV-), 11 asymptomatic HIV seropositive MHS (HIV+) and patients with ARC (N = 15) or AIDS (N = 13), and compared them to 20 matched healthy heterosexual controls. Serum antibody binding to histones, cardiolipin, ss-A, ss-B and Sm was found to be significantly higher in each of the MHS groups studied as compared to controls (P less than 0.001), and was also increased in the HIV+ patients vs. the HIV- group (P less than 0.05). In contrast, no increase in autoantibodies to ss-DNA, ds-DNA, poly(I), poly(G) or RNP were found in any of the groups tested. These results enlarge the spectrum of autoimmunity previously reported in HIV infection and identify a similar pattern to a lesser degree, already present in HIV- MHS, suggesting a role for HIV or concomitant virus infections in its pathogenesis. |
| Databáze: | OpenAIRE |
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