| Autor: |
Annemieke Madder, Bruno Van Mele, James Gardiner, Maria Mercedes Diaz Acevedo, Steven Ballet, Richard Hoogenboom, Jeroen Mangelschots, Lynne J. Waddington, Bruno G. De Geest, Mathieu Bibian |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Journal of materials chemistry. B. 3(5) |
| ISSN: |
2050-7518 |
| Popis: |
The amphiphilic peptide sequence H-Phe-Glu-Phe-Gln-Phe-Lys-OH (MBG-1) is developed as a novel hydrogelator for use in controlled-drug release administration, which is the smallest tunable ionic self-complementary hydrogelating peptide reported to date making it attractive for larger scale preparation. Hydrogelation is demonstrated to result from self-assembly of the peptide into beta-sheet nanofibers that are physically cross-linked by intertwining as well as larger bundle formation. Finally, the release of two small molecule cargos, fluorescein sodium and ciprofloxacin hydrochloride, is demonstrated revealing a two-stage zero-order sustained release profile up to 80% cumulative release over eight days. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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