Association between interleukin-6 polymorphisms and periodontitis in Indian non-smokers
| Autor: | Luigi Nibali, Peter Brett, Isobel Madden, Nikos Donos, Fernando Franch-Chillida |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Linkage disequilibrium Cross-sectional study Population India Dentistry Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide Linkage Disequilibrium Asian People Reference Values Internal medicine Genotype medicine Humans Genetic Predisposition to Disease Periodontitis Promoter Regions Genetic education Genetic Association Studies education.field_of_study Interleukin-6 business.industry Smoking Haplotype Case-control study Middle Aged medicine.disease Cross-Sectional Studies Case-Control Studies Periodontics Female Periodontal Index business |
| Zdroj: | Journal of Clinical Periodontology. 37:137-144 |
| ISSN: | 1600-051X 0303-6979 |
| Popis: | Franch-Chillida F, Nibali L, Madden I, Donos N, Brett P. Association between interleukin-6 polymorphisms and periodontitis in Indian non-smokers. J Clin Periodontol 2010; 37: 137–144. doi: 10.1111/j.1600-051X.2009.01501.x. Abstract Aim: Genetic polymorphisms (SNPs) in the interleukin-6 (IL-6) gene have been associated with the presence of periodontitis. The aim of this study was to investigate the association between five SNPs in the IL-6 promoter region and the periodontal status of a rural Indian population. Materials and Methods: Two hundred and fifty-one systemically healthy volunteers were clinically assessed by a single calibrated examiner and divided into: healthy individuals and periodontitis patients based on the European Workshop on Periodontitis definitions and on a recently suggested definition, which takes into account age and clinical attachment levels. Their genomic DNA was analysed blindly using real-time polymerase chain reaction to study IL-6 variants. The association between genetic factors and the presence of periodontitis was assessed by logistic regression. Results: The IL-6−174 GG genotype was associated with periodontitis in non-smokers and older subjects (>45 years old). No statistically significant associations were detected between IL-6 haplotypes and periodontal status, after adjusting for confounders. Conclusions: The IL-6−174 polymorphism showed some evidence of an association with the periodontal status in non-smokers and older subjects in this rural Indian population. This association might be mediated by the effect of IL-6 on inflammatory responses. |
| Databáze: | OpenAIRE |
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