Electrocatalytic activity of cobalt phthalocyanine CoPc adsorbed on a graphite electrode for the oxidation of reduced L-glutathione (GSH) and the reduction of its disulfide (GSSG) at physiological pH
| Autor: | Rodrigo Cofré, Fethi Bedioui, Nazaré Pereira-Rodrigues, José H. Zagal |
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| Rok vydání: | 2005 |
| Předmět: |
Aqueous solution
Indoles Molecular Structure Chemistry Inorganic chemistry Biophysics chemistry.chemical_element Context (language use) General Medicine Hydrogen-Ion Concentration Electrochemistry Glutathione Amperometry Catalysis Electrochemical gas sensor Electrode Organometallic Compounds Graphite Pyrolytic carbon Disulfides Physical and Theoretical Chemistry Cobalt Electrodes Oxidation-Reduction |
| Zdroj: | Bioelectrochemistry (Amsterdam, Netherlands). 70(1) |
| ISSN: | 1567-5394 |
| Popis: | Modified electrodes coated by adsorbed cobalt phthalocyanines are known to show substantial electrocatalytic activity for the electro-oxidation of several thiols in alkaline aqueous solution. In this context, we explore in this study the electrocatalytic activity of adsorbed cobalt phthalocyanine (CoPc) on ordinary pyrolytic graphite electrode for the oxidation of reduced L-glutathione GSH and the reduction of its disulfide GSSG at physiological pH. To do so, cyclic and rotating disk voltammetries were performed and the amperometric results show that a stable electrochemical sensing material, with good reproducibility and sensitivity (in accordance with the concentrations of GSH expected in biological media), can be easily achieved. This opens the way for the design of an electrochemical sensor able to detect these two analytes in biologically relevant experimental conditions (in terms of pH). |
| Databáze: | OpenAIRE |
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