Estrogen-dependent seasonal adaptations in the immune response of fish
| Autor: | Magdalena Maciuszek, Magdalena Chadzinska, E. Szwejser, B.M. Lidy Verburg-van Kemenade |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
aromatase Cell signaling medicine.drug_class Estrogen receptor Celbiologie en Immunologie Estrogen receptors 03 medical and health sciences Behavioral Neuroscience Endocrinology Immune system Aromatase Immunity medicine Animals Humans fish biology Endocrine and Autonomic Systems Reproduction Fishes Estrogens estrogen receptors Acquired immune system Adaptation Physiological Neurosecretory Systems endocrine disrupting compounds 030104 developmental biology Fish Cell Biology and Immunology Receptors Estrogen Estrogen Immune System Immunology Endocrine disrupting compounds biology.protein WIAS Female Season Seasons season Hormone estrogens |
| Zdroj: | Hormones and Behavior, 88, 15-24 Hormones and Behavior 88 (2017) |
| ISSN: | 0018-506X |
| Popis: | Clinical and experimental evidence shows that estrogens affect immunity in mammals. Less is known about this interaction in the evolutionary older, non-mammalian, vertebrates. Fish form an excellent model to identify evolutionary conserved neuroendocrine-immune interactions: i) they are the earliest vertebrates with fully developed innate and adaptive immunity, ii) immune and endocrine parameters vary with season, and iii) physiology is constantly disrupted by increasing contamination of the aquatic environment.Neuro-immuno-endocrine interactions enable adaption to changing internal and external environment and are based on shared signaling molecules and receptors. The presence of specific estrogen receptors on/in fish leukocytes, implies direct estrogen-mediated immunoregulation. Fish leukocytes most probably are also capable to produce estrogens as they express the . cyp19a and . cyp19b - genes, encoding aromatase cytochrome P450, the enzyme critical for conversion of C19 steroids to estrogens.Immunoregulatory actions of estrogens, vary among animal species, and also with dose, target cell type, or physiological condition (e.g., infected/non-infected, reproductive status). They moreover are multifaceted. Interestingly, season-dependent changes in immune status correlate with changes in the levels of circulating sex hormones. Whereas E2 circulating in the bloodstream is perhaps the most likely candidate to be the physiological mediator of systemic immune-reproductive trade-offs, leukocyte-derived hormones are hypothesized to be mainly involved in local tuning of the immune response. Contamination of the aquatic environment with estrogenic EDCs may violate the delicate and precise allostatic interactions between the endogenous estrogen system and the immune system. This has negative effects on fish health, but will also affect the physiology of its consumers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect