Phalangeal Quantitative Ultrasound and Bone Mineral Density in Evaluating Cortical Bone Loss: A Study in Postmenopausal Women With Primary Hyperparathyroidism and Subclinical Iatrogenic Hyperthyroidism

Autor: Addolorata Scarpiello, I. Raso, Maurizio Angelozzi, Cristiana Cipriani, Emilio D'Erasmo, Teresa Montesano, Elisabetta Romagnoli, Salvatore Minisola
Rok vydání: 2009
Předmět:
Physiology
Endocrinology
Diabetes and Metabolism
Iatrogenic Disease
Hyperthyroidism
Finger Phalanges
Bone Density
Orthopedics and Sports Medicine
Femur
Osteoporosis
Postmenopausal
Ultrasonography
Subclinical infection
Bone mineral
Lumbar Vertebrae
Ultrasound
phalangeal quantitative ultrasound
Middle Aged
Hyperparathyroidism
Primary
Postmenopause
Quantitative ultrasound
medicine.anatomical_structure
Parathyroid Hormone
Iatrogenic hyperthyroidism
Disease Progression
Female
Radiology
subclinical hyperthyroidism
Adult
medicine.medical_specialty
Histology
Urology
Diagnosis
Differential
Young Adult
Internal medicine
medicine
Humans
Radiology
Nuclear Medicine and imaging
primary hyperparathyroidism
Aged
Femoral neck
bone mineral density
Hyperparathyroidism
Postmenopausal women
business.industry
medicine.disease
Radiography
Thyroxine
Endocrinology
Cortical bone
business
Primary hyperparathyroidism
Follow-Up Studies
Zdroj: Journal of Clinical Densitometry. 12:456-460
ISSN: 1094-6950
DOI: 10.1016/j.jocd.2009.08.002
Popis: Twenty-five postmenopausal women with primary hyperparathyroidism (PHPT) and 30 age-matched women with subclinical hyperthyroidism (sHTH) were studied to assess cortical bone loss. One hundred two healthy women were also recruited. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry at lumbar spine (LS), femoral neck (FN) and femoral total (FT), and at one-third of the radius (R). Amplitude-dependent speed of sound (ADSoS) and Ultrasound Bone Profile Index (UBPI) were also evaluated using phalangeal quantitative ultrasound (QUS). A significant correlation was found between QUS and BMD at LS (ADSoS, p < 0.05) and R (ADSoS and UBPI, p < 0.001) in controls. QUS significantly correlated with BMD at LS, FN (p < 0.01), and FT (p < 0.001) in sHTH. No correlations were found in the PHPT group. Mean T-score values of all parameters were significantly lower in patients compared with controls (p < 0.001); however, they did not differ between PHPT and sHTH patients. T-score of R, ADSoS, and UBPI was reduced compared with other sites (p < 0.001) in both diseases. In postmenopausal women with PHPT and sHTH, bone loss is mainly detectable at cortical level. However, qualitative and/or structural changes of bone could account for the lack of correlations between these 2 techniques at cortical sites.
Databáze: OpenAIRE
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