Aneuploidy in Early Miscarriage and its Related Factors
Autor: | Shuyu Wang, Chanwei Jia, Ying Li, Rui Song, Lan Yu, Li Wang, Yang Yang, Yanmin Ma, Yu Liang, Yonglian Lan, Li-Yin Zhou |
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Jazyk: | angličtina |
Rok vydání: | 2015 |
Předmět: |
Adult
Abortion Habitual medicine.medical_specialty Monosomy Aneuploidy lcsh:Medicine Abortion Miscarriage Trisomy 22 Pregnancy medicine Humans Sex Ratio Advanced maternal age In Situ Hybridization reproductive and urinary physiology Gynecology business.industry Incidence (epidemiology) lcsh:R General Medicine Middle Aged Artificial Abortion medicine.disease Parental Age Recurrent Abortion Abortion Spontaneous embryonic structures Original Article Female business |
Zdroj: | Chinese Medical Journal, Vol 128, Iss 20, Pp 2772-2776 (2015) Chinese Medical Journal |
ISSN: | 0366-6999 |
Popis: | Background: Genetic factors are the main cause of early miscarriage. This study aimed to investigate aneuploidy in spontaneous abortion by fluorescence in situ hybridization (FISH) using probes for 13, 16, 18, 21, 22, X and Y chromosomes. Methods: A total of 840 chorionic samples from spontaneous abortion were collected and examined by FISH. We analyzed the incidence and type of abnormal cases and sex ratio in the samples. We also analyzed the relationship between the rate of aneuploidy and parental age, the rate of aneuploidy between recurrent abortion and sporadic abortion, the difference in incidence of aneuploidy between samples from previous artificial abortion and those from no previous induced abortion. Results: A total of 832 samples were finally analyzed. 368 (44.23%) were abnormal, in which 84.24% (310/368) were aneuploidies and 15.76% (58/368) were polyploidies. The first was trisomy16 (121/310), followed by trisomy 22, and X monosomy. There was no significant difference in the rate of aneuploidy in the advanced maternal age group (≥35 years old) and young maternal age group ( |
Databáze: | OpenAIRE |
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