Aneuploidy in Early Miscarriage and its Related Factors

Autor: Shuyu Wang, Chanwei Jia, Ying Li, Rui Song, Lan Yu, Li Wang, Yang Yang, Yanmin Ma, Yu Liang, Yonglian Lan, Li-Yin Zhou
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Chinese Medical Journal, Vol 128, Iss 20, Pp 2772-2776 (2015)
Chinese Medical Journal
ISSN: 0366-6999
Popis: Background: Genetic factors are the main cause of early miscarriage. This study aimed to investigate aneuploidy in spontaneous abortion by fluorescence in situ hybridization (FISH) using probes for 13, 16, 18, 21, 22, X and Y chromosomes. Methods: A total of 840 chorionic samples from spontaneous abortion were collected and examined by FISH. We analyzed the incidence and type of abnormal cases and sex ratio in the samples. We also analyzed the relationship between the rate of aneuploidy and parental age, the rate of aneuploidy between recurrent abortion and sporadic abortion, the difference in incidence of aneuploidy between samples from previous artificial abortion and those from no previous induced abortion. Results: A total of 832 samples were finally analyzed. 368 (44.23%) were abnormal, in which 84.24% (310/368) were aneuploidies and 15.76% (58/368) were polyploidies. The first was trisomy16 (121/310), followed by trisomy 22, and X monosomy. There was no significant difference in the rate of aneuploidy in the advanced maternal age group (≥35 years old) and young maternal age group (
Databáze: OpenAIRE