Resting-state functional EEG connectivity in salience and default mode networks and their relationship to dissociative symptoms during NMDA receptor antagonism
| Autor: | Sara de la Salle, Joelle Choueiry, Dhrasti Shah, Hayley Bowers, Judy McIntosh, Vadim Ilivitsky, Brooke Carroll, Verner Knott |
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| Rok vydání: | 2021 |
| Předmět: |
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medicine.drug_class Rest Clinical Biochemistry Neuroimaging Electroencephalography Toxicology Dissociative Receptors N-Methyl-D-Aspartate Biochemistry Functional Laterality Random Allocation Young Adult 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Double-Blind Method mental disorders medicine Humans Ketamine Biological Psychiatry Default mode network Pharmacology Anesthetics Dissociative medicine.diagnostic_test Resting state fMRI Brain Default Mode Network Cognition Healthy Volunteers 030227 psychiatry Electrophysiology Schizophrenia NMDA receptor Nerve Net Psychology Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 201:173092 |
| ISSN: | 0091-3057 |
| Popis: | N-methyl- d -aspartate receptor (NMDAR) antagonists administered to healthy humans results in schizophrenia-like symptoms, which are thought in part to be related to glutamatergically altered electrophysiological connectivity in large-scale intrinsic functional brain networks. Here, we examine resting-state source electroencephalographic (EEG) connectivity within and between the default mode (DMN: for self-related cognitive activity) and salience networks (SN: for detection of salient stimuli in internal and external environments) in 21 healthy volunteers administered a subanesthetic dose of the dissociative anesthetic and NMDAR antagonist, ketamine. In addition to provoking symptoms of dissociation, which are thought to originate from an altered sense of self that is common to schizophrenia, ketamine induces frequency-dependent increases and decreases in connectivity within and between DMN and SN. These altered interactive network couplings together with emergent dissociative symptoms tentatively support an NMDAR-hypofunction hypothesis of disturbed electrophysiologic connectivity in schizophrenia. |
| Databáze: | OpenAIRE |
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