Feasibility of endometrial sampling by vaginal tampons in women with Lynch syndrome

Autor: Marian J.E. Mourits, Bettien M. van Hemel, N Werner, Harry Hollema, Geertruida H. de Bock, J. M. Woolderink, Erwin Geuken
Přispěvatelé: Damage and Repair in Cancer Development and Cancer Treatment (DARE), Life Course Epidemiology (LCE), Targeted Gynaecologic Oncology (TARGON), ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
MICROSATELLITE INSTABILITY
PHENOTYPE
Endometrial sampling
Endometrium
0302 clinical medicine
Endometrial cancer
Pregnancy
Cytology
Medicine
Prospective Studies
MUTATION
030219 obstetrics & reproductive medicine
Surveillance
lcsh:Public aspects of medicine
METHYLATION
MLH1
Obstetrics and Gynecology
General Medicine
Lynch syndrome
030220 oncology & carcinogenesis
Adenocarcinoma
Female
medicine.symptom
Research Article
medicine.medical_specialty
Tampons
Visual analogue scale
Reproductive medicine
Asymptomatic
lcsh:Gynecology and obstetrics
03 medical and health sciences
Humans
Menstrual Hygiene Products
lcsh:RG1-991
Gynecology
business.industry
Microsatellite instability
lcsh:RA1-1270
ADENOCARCINOMA
CANCER-RISKS
medicine.disease
equipment and supplies
HYPERMETHYLATION
Colorectal Neoplasms
Hereditary Nonpolyposis
GENE
Reproductive Medicine
Feasibility Studies
business
Zdroj: BMC Women's Health, 20(1):54. BioMed Central Ltd.
BMC Women's Health
BMC Women's Health, Vol 20, Iss 1, Pp 1-7 (2020)
ISSN: 1472-6874
Popis: BackgroundEndometrial sampling for the surveillance of women with Lynch syndrome is an invasive and painful procedure. The aim of this study was to evaluate the feasibility of a less invasive procedure of collecting vital cells by vaginal tampons.MethodsThis was a prospective feasibility study of women scheduled to undergo annual gynecological surveillance, including endometrial sampling. We included consecutive asymptomatic women with Lynch syndrome or first-degree relatives and asked them to insert a vaginal tampon 2–4 h before attending their outpatient appointment. Feasibility was evaluated by the following metrics: patient acceptance, pain intensity of each procedure (assessed by visual analog scale; range 0–10), and the presence of vital cells obtained by tampon-based or endometrial sampling methods. Two pathologists independently evaluated all samples.ResultsIn total, 25 of 32 approached women completed the tampon-based procedure, with 23 of these subsequently undergoing invasive endometrial sampling. The median visual analog scale scores for tampon use and invasive endometrial sampling were 0 (range, 0–10) and 5.5 (range, 1–10) (p ConclusionsTampon-based endometrial surveillance was a well-accepted and non-painful procedure, and although tampons contained vital cells, they did not provide endometrial cells. However, this study was limited to asymptomatic women with Lynch syndrome (no endometrial pathology), indicating that research is needed to evaluate whether the tampon method has any utility for endometrial surveillance in women with Lynch syndrome.
Databáze: OpenAIRE
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