Tau associated peripheral and central neurodegeneration: Identification of an early imaging marker for tauopathy
| Autor: | Andrew Marshall, Fernanda Arenas, Morgan Cundiff, Katie E. Frizzi, Matthew Jones, Sze Hway Lim, Xiajun Zhou, Rayaz A. Malik, Georgios Ponirakis, Isabel Constantino, Lucie S. Guernsey, Monty Silverdale, Alexandra Marquez, Christopher Kobylecki, Nabeel Muttalib, Corinne G. Jolivalt, Maryam Ferdousi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Genetically modified mouse Pathology medicine.medical_specialty Stromal cell Peripheral neuropathy Mice Transgenic tau Proteins Article lcsh:RC321-571 Cornea 03 medical and health sciences Mice 0302 clinical medicine Alzheimer Disease mental disorders medicine Animals Humans Neurodegeneration Pathological lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Memory Disorders Microscopy Confocal business.industry Peripheral Nervous System Diseases Middle Aged medicine.disease Peripheral 030104 developmental biology Neurology Tauopathies Corneal confocal microscopy Memory deficits Frontotemporal Dementia Nerve Degeneration Female Tauopathy Tau business 030217 neurology & neurosurgery Frontotemporal dementia |
| Zdroj: | Neurobiol Dis Neurobiology of Disease, Vol 151, Iss, Pp 105273-(2021) |
| Popis: | Pathological hyperphosphorylated tau is a key feature of Alzheimer's disease (AD) and Frontotemporal dementia (FTD). Using transgenic mice overexpressing human non-mutated tau (htau mice), we assessed the contribution of tau to peripheral and central neurodegeneration. Indices of peripheral small and large fiber neuropathy and learning and memory performances were assessed at 3 and 6 months of age. Overexpression of human tau is associated with peripheral neuropathy at 6 months of age. Our study also provides evidence that non-mutated tau hyperphosphorylation plays a critical role in memory deficits. In addition, htau mice had reduced stromal corneal nerve length with preservation of sub-basal corneal nerves, consistent with a somatofugal degeneration. Corneal nerve degeneration occurred prior to any cognitive deficits and peripheral neuropathy. Stromal corneal nerve loss was observed in patients with FTD but not AD. Corneal confocal microscopy may be used to identify early neurodegeneration and differentiate FTD from AD. |
| Databáze: | OpenAIRE |
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