Effects of boron on structure and antioxidative activities of spleen in rats
| Autor: | Shenghe Li, Youfang Gu, Zhongtao Tang, Jin Guangming, Qianqian Hu, Qiao Enmei, Erhui Jin |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
inorganic chemicals
Male medicine.medical_specialty Antioxidant Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry chemistry.chemical_element Spleen Biochemistry Antioxidants Inorganic Chemistry Superoxide dismutase Rats Sprague-Dawley chemistry.chemical_compound Internal medicine Malondialdehyde medicine Animals Boron chemistry.chemical_classification Glutathione Peroxidase biology Dose-Response Relationship Drug Superoxide Dismutase Glutathione peroxidase Biochemistry (medical) General Medicine Organ Size Catalase Enzymes Dose–response relationship Endocrinology medicine.anatomical_structure chemistry biology.protein Female |
| Zdroj: | Biological trace element research. 158(1) |
| ISSN: | 1559-0720 |
| Popis: | In order to determine the relationship between boron and development of the spleen, especially in the promoting biological effects, we examined the effects of different levels of boron on weight, organ index, microstructure, and antioxidative activities of the spleen in rats. Sprague-Dawley (SD) rats were selected and treated with different concentrations of boron, and then, the organs were resected and weighed. One half of the tissue was fixed and embedded in paraffin to observe tissue structure changes. The other half of the tissue was homogenated for determining the antioxidant activities. The results showed that 40 mg/L of boron could increase weight, organ indexes, and antioxidant capacity of spleens and improve the spleen tissue structure, while the boron concentration above 80 mg/L could decrease weight, organ indexes, and antioxidant capacity of spleens and damage the spleen tissue structure. The higher the concentration, the more serious the damage was. Especially at the concentration of 640 mg/L, it could significantly inhibit the development of the spleen and even exhibit toxic effect. Hence, low boron concentration played a protective role in the development of the spleen, while high boron concentration could damage the organs and even produce toxic effect. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink