High-Mobility Group Box Protein 1 Is an Independent Prognostic Marker for All-Cause Mortality in Patients With Dilated Cardiomyopathy

Autor: Andreas Kümmel, Stefan Gross, Rico Feldtmann, Bishwas Chamling, Anne Strohbach, Kristin Lehnert, Martin Bahls, Lisa Loerzer, Katharina Moormann, Jeannine Witte, Alexander Riad, Marcus Dörr, Jens Fielitz, Stephan B. Felix
Rok vydání: 2022
Předmět:
Zdroj: The American Journal of Cardiology. 178:119-123
ISSN: 0002-9149
DOI: 10.1016/j.amjcard.2022.05.014
Popis: High-mobility group box protein 1 (HMGB1) is released during tissue damage and activates the innate immune system through toll-like receptor 4. Because mortality in dilated cardiomyopathy (DCM) is associated with activation of the innate immune system, we hypothesized that HMGB1 possesses a prognostic value in estimating mortality in patients with DCM. We determined HMGB1 and N-terminal B-type natriuretic peptide (NT-proBNP) levels in 67 patients with DCM (12 women, mean age 53.6 ± 1.5 years). Kaplan-Meier analyzes revealed that higher levels of HMGB1 and NT-proBNP are related to increased all-cause mortality. Multivariable Cox regression confirmed HMGB1 as a risk factor for mortality in patients with DCM, independent of NT-proBNP, age, and gender (hazard ratio per 1 SD 1.920, 95% confidence interval 1.401 to 2.631, plt;0.001). HMGB1 is a promising candidate to estimate the prognosis of patients with DCM.
Databáze: OpenAIRE
Externí odkaz: