Immunotoxic effects of sodium tungstate dihydrate on female B6C3F1/N mice when administered in drinking water

Autor:	Rachel P. Frawley, Ron Herbert, Susan A. Elmore, Michelle J. Hooth, Dori R. Germolec, Mamta Behl, Matthew J. Smith, Lauren M. Staska, Kimber L. White, Rebecca R. Moore, Grace E. Kissling
Rok vydání:	2016
Předmět:	Cytotoxicity Immunologic 0301 basic medicine T-Lymphocytes Immunology Toxicology Article Mice 03 medical and health sciences chemistry.chemical_compound Immune system Immunity Splenocyte medicine Animals Sodium tungstate Progenitor cell Cells Cultured Cell Proliferation Immunity Cellular Mice Inbred C3H Innate immune system Chemistry Drinking Water Environmental Exposure Environmental exposure Tungsten Compounds Hematopoiesis Rats Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Female Bone marrow
Zdroj:	Journal of Immunotoxicology. 13:666-675
ISSN:	1547-6901 1547-691X
DOI:	10.3109/1547691x.2016.1154118
Popis:	Tungsten is a naturally occurring, high tensile strength element that has been used in a number of consumer products. Tungsten has been detected in soil, waterways, groundwater, and human tissue and body fluids. Elevated levels of tungsten in urine were reported for populations exposed to tungstate in drinking water in areas where natural tungsten formations were prevalent. Published reports indicated that sodium tungstate may modulate hematopoiesis, immune cell populations, and immune responses in rodent models. The objective of this study was to assess potential immunotoxicity of sodium tungstate dihydrate (STD), a drinking water contaminant. Female B6C3F1/N mice received 0–2000 mg STD/L in their drinking water for 28 days, and were evaluated for effects on immune cell populations in spleen and bone marrow, and humoral-mediated, cell-mediated, and innate immunity. Three different parameters of cell-mediated immunity were similarly affected at 1000 mg STD/L. T-cell proliferative responses against allogeneic leukocytes and anti-CD3 were decreased 32%, and 21%, respectively. Cytotoxic T-lymphocyte activity was decreased at all effector:target cell ratios examined. At 2000 mg STD/L, the absolute numbers of CD3+ T-cell progenitor cells in bone marrow were increased 86%, but the alterations in B-lymphocyte and other progenitor cells were not significant. There were no effects on bone marrow DNA synthesis or colony forming capabilities. STD-induced effects on humoral-mediated immunity, innate immunity, and splenocyte sub-populations were limited. Enhanced histopathology did not detect treatment-related lesions in any of the immune tissues. These data suggest exposure to STD in drinking water may adversely effect cell-mediated immunity.
Databáze:	OpenAIRE
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