Activation of the brain-specific neurogranin gene in murine T-cell lymphomas by proviral insertional mutagenesis
| Autor: | Finn Skou Pedersen, Mads Rasmussen, Annette Balle Sørensen, Matthias Wabl, Bruce Wang, Anne Ahlmann Nielsen, Kristin Rós Kjartansdóttir |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Transcriptional Activation
T cell Mutagenesis (molecular biology technique) Biology Lymphoma T-Cell Article Insertional mutagenesis Mice Proviruses Murine leukemia virus Genetics medicine Animals Neurogranin Gene Regulation of gene expression Gene Expression Regulation Leukemic Brain General Medicine medicine.disease biology.organism_classification Molecular biology Lymphoma Leukemia Virus Murine Mutagenesis Insertional medicine.anatomical_structure Cancer research |
| Zdroj: | Nielsen, A A, Kjartansdóttir, K R, Rasmussen, M H, Sørensen, A B, Wang, B, Wabl, M & Pedersen, F S 2009, ' Activation of the brain-specific neurogranin gene in murine T-cell lymphomas by proviral insertional mutagenesis ', Gene, pp. 55-62 . https://doi.org/10.1016/j.gene.2009.04.003 |
| Popis: | Udgivelsesdato: 2009-Apr-17 Neurogranin (Nrgn) is a highly expressed brain-specific protein, which sequesters calmodulin at low Ca(2+)-levels. We report here on retroviral activation of the Nrgn gene in tumors induced by the T-cell lymphomagenic SL3-3 murine leukemia virus. We have performed a systematic expression analysis of Nrgn in various mouse tissues and SL3-3 induced T-cell tumors. This demonstrated that insertional activation of Nrgn increased RNA and protein expression levels to that observed in brain. Furthermore, elevated Nrgn expression was also observed in some T-cell tumors with no detected provirus integrations into this genomic region. The presented data demonstrate that Nrgn can be produced at high levels outside the brain, and suggest a novel oncogenic role in T-cell lymphomas in mice. |
| Databáze: | OpenAIRE |
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