Decreased Androgen Receptor Expression Is Associated With Distant Metastases in Patients With Androgen Receptor–Expressing Triple-Negative Breast Carcinoma
| Autor: | Kwame Torgbe, Yan Peng, Venetia R. Sarode, Lisa M. Sutton, Dengfeng Cao, Kyle Molberg, Barbara Haley |
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| Rok vydání: | 2012 |
| Předmět: |
Oncology
medicine.medical_specialty Receptor ErbB-2 Breast Neoplasms Disease Adenocarcinoma Breast cancer Internal medicine Biomarkers Tumor medicine Carcinoma Humans Neoplasm Metastasis Triple-negative breast cancer business.industry General Medicine Prognosis medicine.disease Androgen receptor Ki-67 Antigen Receptors Estrogen Receptors Androgen Immunohistochemistry Female Triple-Negative Breast Carcinoma Receptors Progesterone Breast carcinoma business |
| Zdroj: | American Journal of Clinical Pathology. 138:511-516 |
| ISSN: | 1943-7722 0002-9173 |
| Popis: | To characterize prognostic values of androgen receptor (AR) in triple-negative (TN) breast cancers, we investigated AR expression status and levels, explored an association of AR expression with metastatic disease, and correlated AR expression with Ki-67 in TN invasive breast carcinomas. AR expression was analyzed with immunohistochemistry in 121 cases of TN tumors. Thirty-nine cases had distant metastatic disease and 82 had locoregional disease only. AR was positive in 38 (31.4%) of the 121 cases. Our results indicate that among the AR-positive TN tumors, distant metastases are significantly associated with lower expression of AR compared with cases with only locoregional disease, and that AR expression negatively correlates with Ki-67 expression. These findings suggest that decreased intratumoral AR expression may be predictive of distant metastatic disease and AR expression levels may have potential prognostic value in AR-expressing TN tumors. |
| Databáze: | OpenAIRE |
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