Monocytes in the Tumor Microenvironment
| Autor: | Stefania Canè, Vincenzo Bronte, Stefano Ugel, Francesco De Sanctis |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Angiogenesis medicine.medical_treatment Biology Monocytes Pathology and Forensic Medicine Immune tolerance 03 medical and health sciences 0302 clinical medicine Immune system Neoplasms medicine Tumor Microenvironment cancer Animals Humans innate immunity Tumor microenvironment Innate immune system immunotherapy monocytes tumor microenvironment Effector Cancer Immunotherapy medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis Cancer research Tumor Escape |
| Zdroj: | Annual review of pathology. 16 |
| ISSN: | 1553-4014 |
| Popis: | Immunotherapy has revolutionized cancer treatment over the past decade. Nonetheless, prolonged survival is limited to relatively few patients. Cancers enforce a multifaceted immune-suppressive network whose nature is progressively shaped by systemic and local cues during tumor development. Monocytes bridge innate and adaptive immune responses and can affect the tumor microenvironment through various mechanisms that induce immune tolerance, angiogenesis, and increased dissemination of tumor cells. Yet monocytes can also give rise to antitumor effectors and activate antigen-presenting cells. This yin-yang activity relies on the plasticity of monocytes in response to environmental stimuli. In this review, we summarize current knowledge of the ontogeny, heterogeneity, and functions of monocytes and monocyte-derived cells in cancer, pinpointing the main pathways that are important for modeling the immunosuppressive tumor microenvironment. |
| Databáze: | OpenAIRE |
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