MicroRNAs relate to early worsening of renal function in patients with acute heart failure

Autor: Pim van der Harst, Mattia A.E. Valente, Michael M. Givertz, Peter van der Meer, Gad Cotter, Beth A. Davison, John R. Teerlink, Adriaan A. Voors, Hans L. Hillege, Marco Metra, Eline L. Vegter, Piotr Ponikowski, Eugene Berezikov, Howard C. Dittrich, Dirk J. van Veldhuisen, Jozine M. ter Maaten, Rudolf A. de Boer, Daniela Schmitter, Ekaterina S. Ovchinnikova, Noemi Bruno, John G.F. Cleland, Daniel M. Bloomfield, Christopher M. O'Connor, Yigal M. Pinto
Přispěvatelé: Amsterdam Cardiovascular Sciences, Cardiology, Cardiovascular Centre (CVC), Life Course Epidemiology (LCE), Groningen Kidney Center (GKC), Stem Cell Aging Leukemia and Lymphoma (SALL), Restoring Organ Function by Means of Regenerative Medicine (REGENERATE)
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
Worsening renal function
ISCHEMIA-REPERFUSION INJURY
HFREF
Disease
030204 cardiovascular system & hematology
DISEASE
HFPEF
Pathogenesis
chemistry.chemical_compound
Circulating microRNA
0302 clinical medicine
Medicine
Renal Insufficiency
Diuretics
Acute kidney injury
Creatinine
Acute Disease
Disease Progression
Cardiology
Female
Cardiology and Cardiovascular Medicine
Glomerular Filtration Rate
EXPRESSION
medicine.medical_specialty
BIOMARKERS
ACUTE KIDNEY INJURY
Renal function
Enzyme-Linked Immunosorbent Assay
Real-Time Polymerase Chain Reaction
03 medical and health sciences
Double-Blind Method
Internal medicine
Humans
PLAYERS
METAANALYSIS
Aged
Retrospective Studies
Heart Failure
business.industry
Acute heart failure
Retrospective cohort study
medicine.disease
MicroRNAs
Circulating MicroRNA
Early Diagnosis
030104 developmental biology
Endocrinology
Gene Expression Regulation
chemistry
Xanthines
Heart failure
business
Follow-Up Studies
Zdroj: International journal of cardiology, 203, 564-569. Elsevier Ireland Ltd
International Journal of Cardiology, 203, 564-569. ELSEVIER IRELAND LTD
ISSN: 0167-5273
Popis: Background: Deregulation of microRNAs (miRNAs) may be involved in the pathogenesis of heart failure (HF) and renal disease. Our aim is to describe miRNA levels related to early worsening renal function in acute HF patients.Method and results: We studied the association between 12 circulating miRNAs and Worsening Renal Function (WRF; defined as an increase in the serum creatinine level of 0.3 mg per deciliter or more from admission to day 3), absolute change in creatinine and Neutrophil Gelatinase Associated Lipocalin (NGAL) from admission to day 3 in 98 patients hospitalized for acute HF.At baseline, circulating levels of all miRNAs were lower in patients with WRF, with statistically significant decreased levels of miR-199a-3p, miR-423-3p, and miR-let-7i-5p (p-value Conclusions: Our results show that the levels of circulating miRNAs at hospital admission for acute HF were consistently lower in patients who developed worsening of renal function. MiR-199a-3p was the best predictor of WRF in these patients. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
Databáze: OpenAIRE
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