Pre-seizure architecture of the local connections of the epileptic focus examined via graph-theory
| Autor: | Filomena Fuggetta, Placido Bramanti, F. Miraglia, Paolo Maria Rossini, Catello Vollono, Fabrizio Vecchio, Beatrice Cioni |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male Drug Resistant Epilepsy Focus (geometry) eLORETA Epilepsy Functional connectivity Graph theory sEEG Seizure Small-world Sensory Systems Neurology Neurology (clinical) Physiology (medical) Stereoelectroencephalography 03 medical and health sciences 0302 clinical medicine medicine Connectome Humans Theta Rhythm Baseline (configuration management) Cerebral Cortex medicine.disease Settore MED/26 - NEUROLOGIA Alpha Rhythm 030104 developmental biology Female Epileptic seizure medicine.symptom Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 127(10) |
| ISSN: | 1872-8952 |
| Popis: | Objective Epilepsy is characterized by unpredictable and sudden paroxysmal neuronal firing occurrences and sometimes evolving in clinically evident seizure. To predict seizure event, small-world characteristic in nine minutes before seizure, divided in three 3-min periods (T0, T1, T2) were investigated. Methods Intracerebral recordings were obtained from 10 patients with drug resistant focal epilepsy examined by means of stereotactically implanted electrodes; analysis was focused in a period of low spiking (Baseline) and during two seizures. Networks’ architecture is undirected and weighted. Electrodes’ contacts close to epileptic focus are the vertices, edges are weighted by mscohere (=magnitude squared coherence). Results Differences were observed between Baseline and T1 and between Baseline and T2 in theta band; and between Baseline and T1, Baseline and T2, and near-significant difference between T0 and T2 in Alpha 2 band. Moreover, an intra-band index was computed for small worldness as difference between Theta and Alpha 2. It was found a growing index trend from Baseline to T2. Conclusions Cortical network features a specific pre-seizure architecture which could predict the incoming epileptic seizure. Significance Through this study future researches could investigate brain connectivity modifications approximating a clinical seizure also in order to address a preventive therapy. |
| Databáze: | OpenAIRE |
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