Plasma disposition and tissue residue of Moxifloxacin in Japanese quails (Coturnix japonica) following different routes of administration
| Autor: | Sherifa Hasabelnaby, Ayman Goudah |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Disposition kinetics Moxifloxacin Tissue residue Cmax Administration Oral Biological Availability Coturnix Injections Intramuscular Random Allocation Oral administration Internal medicine medicine Animals Chromatography High Pressure Liquid Kidney biology Chemistry Coturnix japonica General Medicine Disposition biology.organism_classification Anti-Bacterial Agents medicine.anatomical_structure Endocrinology Injections Intravenous Female Animal Science and Zoology Fluoroquinolones Half-Life Food Science medicine.drug |
| Zdroj: | British Poultry Science. 55:693-698 |
| ISSN: | 1466-1799 0007-1668 |
| Popis: | The disposition kinetics and the plasma availability of moxifloxacin were investigated in Japanese quails (Coturnix japonica) following different routes of administration at 5 mg/kg body weight. Tissue residue profiles (liver, kidney, lung and muscle) and plasma were also studied after multiple intramuscular and oral administrations of 5 mg/kg body weight, once daily for 5 consecutive days. Following intravenous injection, plasma concentration-time curves were best described by a two-compartment open model. After intramuscular and oral administration of moxifloxacin, the peak plasma concentrations (Cmax) were 2.14 and 1.94 μg/ml and were obtained at 1.40 and 1.87 h (Tmax), post administration, respectively. The systemic bioavailabilities following intramuscular and oral administration, respectively, of moxifloxacin were 92.48 and 87.94%. 6. Tissue concentrations following i.m. and p.o. administration were highest in liver and kidney, respectively, and decreased in the following order: plasma, lung and muscle. No moxifloxacin residues were detected in tissues and plasma after 120 h after i.m. or oral administration. |
| Databáze: | OpenAIRE |
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