Biochemistry of Packed Red Blood Cell Concentrates Stored in PAGGS-Sorbitol Solution for 42 Days
| Autor: | N. Mores, E. Fagiolo, Pelliccetti A, Littarru Gp, S. Lippa |
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| Rok vydání: | 1987 |
| Předmět: |
Glucose utilization
Erythrocytes Acid–base homeostasis Sodium Chloride Phosphates Blood cell Hemoglobins Adenosine Triphosphate medicine Humans Sorbitol Guanosine Chemistry Adenine Erythrocyte Aging Hematology General Medicine Hydrogen-Ion Concentration Red blood cell Glucose medicine.anatomical_structure Hematocrit Atp level Biochemistry Blood Preservation Potassium PAGGS-sorbitol solution |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1423-0410 0042-9007 |
| DOI: | 10.1159/000461669 |
| Popis: | We investigated metabolic, blood gas and acid-base balance modifications of erythrocyte concentrates resuspended in PAGGS-sorbitol solution during 6 weeks of storage. Glucose utilization was impaired during the last 2 weeks, while the intraerythrocytic ATP level decreased only 50% from the 1st to the 6th week. The K+ and Hb concentration in the medium showed a progressive increase which was more pronounced during the last 2 weeks. The decrease in pH progressed to reach 6.27 at the 6th week of storage. Intraerythrocytic 2,3-DPG dropped rapidly in the course of the 1st week and the percentage of oxyhemoglobin showed a remarkable increase after the 1st week (90%). Our data suggest that erythrocyte concentrates in PAGGS-sorbitol should be transfused, for optimal efficacy, within 4 weeks. |
| Databáze: | OpenAIRE |
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