Citrus bergamia powder: Antioxidant, antimicrobial and anti-inflammatory properties
| Autor: | Diana Di Gioia, Stefania Frassinetti, Laura Pucci, Vincenzo Longo, Giovanni Dinelli, Morena Gabriele, Leonardo Caltavuturo, Lidia Montero |
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| Přispěvatelé: | Gabriele, Morena, Frassinetti, Stefania, Caltavuturo, Leonardo, Montero, Lidia, Dinelli, Giovanni, Longo, Vincenzo, Di Gioia, Diana, Pucci, Laura, Consiglio Nazionale delle Ricerche |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
HMEC-1 Antioxidant LPS medicine.drug_class medicine.medical_treatment Endothelial activation and dysfunction Medicine (miscellaneous) medicine.disease_cause Probiotic Bergamot fruit Anti-inflammatory 03 medical and health sciences Flavonols medicine TX341-641 Food science MIC chemistry.chemical_classification 030109 nutrition & dietetics Nutrition and Dietetics Nutrition. Foods and food supply Probiotics food and beverages Pathogenic bacteria Antimicrobial Ascorbic acid 030104 developmental biology Biochemistry chemistry Polyphenol Citrus bergamia Food Science |
| Zdroj: | Journal of Functional Foods, Vol 31, Iss, Pp 255-265 (2017) Journal of Functional Foods 31 (2017): 255–265. doi:10.1016/j.jff.2017.02.007 info:cnr-pdr/source/autori:Morena Gabriele, Stefania Frassinetti, Leonardo Caltavuturo, Lidia Montero, Giovanni Dinelli, Vincenzo Longo, Diana Di Gioia, Laura Pucci/titolo:Citrus bergamia powder: antioxidant, antimicrobial and anti-inflammatory properties/doi:10.1016%2Fj.jff.2017.02.007/rivista:Journal of Functional Foods/anno:2017/pagina_da:255/pagina_a:265/intervallo_pagine:255–265/volume:31 Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | Bergamot whole-fruit powder was analyzed for total polyphenols, flavonoids, flavonols and ascorbic acid content and tested for in vitro and ex vivo antioxidant activity. The flavonoids profile was further characterized via HPLC-DAD-MS/MS and the most abundant flavonoids were quantified. The antimicrobial activity against potentially pathogenic bacteria and the effect on beneficial gut bacteria were determined. Lastly, we evaluated the effects of bergamot extract on endothelial alterations in LPS-stimulated human microvascular endothelial cells (HMEC-1). Our data demonstrated that bergamot powder possesses in vitro and ex vivo antioxidant activity, shows a selective inhibition against pathogenic strains and growth stimulation effects on some beneficial gut bacteria. Moreover, it protects HMEC-1 from LPS-induced activation and dysfunction and reduces the resulting endoplasmic reticulum stress. The relationship between isolated flavonoids and the protective effects are discussed. In conclusion, bergamot whole-fruit powder possesses beneficial health effects that makes it a potentially useful material for the nutraceutical industry. This study was supported by CNR (Consiglio Nazionale delle Ricerche, Italy) and by Farmanatura, Italy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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