Sensitivity variation of doped Fricke gel irradiated with monochromatic synchrotron X rays between 33.5 and 80 keV
| Autor: | Jean-François Le Bas, Marie-Claude Biston, Jacques Balosso, Anne-Marie Charvet, François Estève, Aurélie Joubert, Hélène Elleaume, Stéphanie Corde, Jean-François Adam |
|---|---|
| Přispěvatelé: | Serduc, Raphael, Rayonnement Synchrotron et Recherche Medicale (RSRM), European Synchrotron Radiation Facility (ESRF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Imagerie par Résonance Magnétique (IRM), CHU Grenoble, Département de cancérologie et radiothérapie, Université Joseph Fourier - Grenoble 1 (UJF)-European Synchrotron Radiation Facility (ESRF)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 2005 |
| Předmět: |
Magnetic Resonance Spectroscopy
030218 nuclear medicine & medical imaging law.invention 0302 clinical medicine law Neoplasms MESH: Neoplasms MESH: Radiotherapy Dosage MESH: Radiotherapy Planning Computer-Assisted Radiation Radiological and Ultrasound Technology Relaxation (NMR) Radiotherapy Dosage Barium General Medicine Photoelectric effect MESH: Iothalamic Acid Synchrotron 030220 oncology & carcinogenesis Calibration MESH: Synchrotrons MESH: Radiation Dosage MESH: Ions Materials science MESH: Gels MESH: Barium Sulfate chemistry.chemical_element Radiation Dosage MESH: Calibration Ion MESH: X-Rays 03 medical and health sciences MESH: Dose-Response Relationship Radiation Radiology Nuclear Medicine and imaging Irradiation Radiometry Ions MESH: Magnetic Resonance Spectroscopy business.industry Radiotherapy Planning Computer-Assisted X-Rays Radiochemistry MESH: Radiometry Public Health Environmental and Occupational Health Dose-Response Relationship Radiation Iothalamic Acid chemistry Monochromatic color Barium Sulfate Nuclear medicine business Gels Synchrotrons |
| Zdroj: | Radiation Protection Dosimetry Radiation Protection Dosimetry, Oxford University Press (OUP), 2005, 117 (4), pp.425-31. ⟨10.1093/rpd/nci313⟩ |
| ISSN: | 1742-3406 0144-8420 |
| DOI: | 10.1093/rpd/nci313 |
| Popis: | International audience; An experimental binary radiotherapy proposes the concomitant use of a high-Z compound and synchrotron X rays for enhancing radiation dose selectively in tumours by a photoelectric effect. This study aimed at measuring the resulting dose enhancement in irradiated material. A doped Fricke gel dosemeter model was manufactured with 10 mg ml(-1) of iodine (Telebrix) or barium (Micropaque). Samples were irradiated with a monochromatic synchrotron beam at 33.5, 50, 65 and 80 keV. The ensuing enhancement of the sensitivity of the dosemeter was derived from the nuclear magnetic resonance relaxation rates measured at different X-ray doses. Our results demonstrate (1) the preservation of a linear relationship between relaxation rates and X-ray doses for dosemeters doped with high-Z atoms and (2) a clear energy-dependent sensitivity enhancement for barium-doped Fricke gels. This enhancement was neither reproducible with iodinated compounds nor clearly related to the expected dose enhancement factor. However 1% barium sulphate in the gel could significantly improve the gel's response when it was irradiated by low-energy X rays. |
| Databáze: | OpenAIRE |
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