Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases
| Autor: | Adam R. Offenbacher, Theodore R. Holman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Models
Molecular Cell signaling Allosteric regulation Pharmaceutical Science Review Catalysis Substrate Specificity Analytical Chemistry Small Molecule Libraries Turn (biochemistry) lcsh:QD241-441 03 medical and health sciences Lipoxygenase Allosteric Regulation Protein Domains lcsh:Organic chemistry Drug Discovery Animals Physical and Theoretical Chemistry C-H activation Plant Proteins 030304 developmental biology chemistry.chemical_classification 0303 health sciences biology Chemistry Effector Fatty Acids 030302 biochemistry & molecular biology Organic Chemistry Fatty acid Lipoxygenases Plants protein allostery Small molecule substrate selectivity Enzyme Biochemistry Chemistry (miscellaneous) kinetic isotope effects biology.protein hydrogen tunneling Molecular Medicine Oxidation-Reduction |
| Zdroj: | Molecules, Vol 25, Iss 3374, p 3374 (2020) Molecules |
| ISSN: | 1420-3049 |
| Popis: | Lipoxygenases (LOXs) catalyze the (per) oxidation of fatty acids that serve as important mediators for cell signaling and inflammation. These reactions are initiated by a C-H activation step that is allosterically regulated in plant and animal enzymes. LOXs from higher eukaryotes are equipped with an N-terminal PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain that has been implicated to bind to small molecule allosteric effectors, which in turn modulate substrate specificity and the rate-limiting steps of catalysis. Herein, the kinetic and structural evidence that describes the allosteric regulation of plant and animal lipoxygenase chemistry by fatty acids and their derivatives are summarized. |
| Databáze: | OpenAIRE |
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