Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization
| Autor: | Qian-Rong Qi, Zeng-Ming Yang, Ru-Juan Zuo, Ji-Long Liu, Tong-Song Wang, Xu-Yu Zhao, Xiao-Wei Gu |
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| Rok vydání: | 2015 |
| Předmět: |
MAPK/ERK pathway
medicine.medical_specialty Cellular differentiation genetic processes Biology Stat3 Signaling Pathway Cell Line Polyploidy Mice Polyploid Pregnancy Report Internal medicine CDC2 Protein Kinase Decidua medicine Animals Humans Decidual cells Molecular Biology Transcription factor Progesterone Cyclin-dependent kinase 1 Superoxide Dismutase Ovary Uterus fungi food and beverages Decidualization pathological conditions signs and symptoms Cell Biology Flow Cytometry Cyclin-Dependent Kinases Cell biology Repressor Proteins Endocrinology Microscopy Fluorescence Hepatocytes Pregnancy Animal Female DNA Damage Signal Transduction Developmental Biology |
| Zdroj: | Cell Cycle. 14:1842-1858 |
| ISSN: | 1551-4005 1538-4101 |
| DOI: | 10.1080/15384101.2015.1033593 |
| Popis: | Polyploid decidual cells are specifically differentiated cells during mouse uterine decidualization. However, little is known about the regulatory mechanism and physiological significance of polyploidization in pregnancy. Here we report a novel role of E2F8 in the polyploidization of decidual cells in mice. E2F8 is highly expressed in decidual cells and regulated by progesterone through HB-EGF/EGFR/ERK/STAT3 signaling pathway. E2F8 transcriptionally suppresses CDK1, thus triggering the polyploidization of decidual cells. E2F8-mediated polyploidization is a response to stresses which are accompanied by decidualization. Interestingly, polyploidization is not detected during human decidualization with the down-regulation of E2F8, indicating differential expression of E2F8 may lead to the difference of decidual cell polyploidization between mice and humans. |
| Databáze: | OpenAIRE |
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