Efficacy and tolerability of enteric-coated naproxen in the treatment of osteoarthritis and rheumatoid arthritis: A double-blind comparison with standard naproxen followed by an open-label trial
| Autor: | Hyman Tannenbaum, Anthony S. Russell, S. H. K. Huang, Nicholas Bellamy, Claire Bombardier, J. Campbell, André D. Beaulieu, Ménard Ha, M. Willans, G. R. Kraag |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Naproxen Analgesic Osteoarthritis Gastroenterology Arthritis Rheumatoid Double-Blind Method Internal medicine Arthropathy medicine Humans Antipyretic Aged business.industry General Medicine Middle Aged medicine.disease Enteric coating Surgery Tolerability Rheumatoid arthritis Female Tablets Enteric-Coated business medicine.drug |
| Zdroj: | Current Medical Research and Opinion. 12:640-651 |
| ISSN: | 1473-4877 0300-7995 |
| DOI: | 10.1185/03007999209111531 |
| Popis: | SummaryOne hundred and twenty-three patients with osteoarthritis (n = 50) or rheumatoid arthritis (n = 73) were enrolled in a 6-week, double-blind, randomized, controlled, parallel trial comparing enteric-coated naproxen with standard naproxen. Ninety-eight patients subsequently entered a 20-week, open-label trial of enteric-coated naproxen. The study demonstrated that naproxen in both its standard formulation and its new enteric-coated formulation is a highly effective form of therapy for osteoarthritis and rheumatoid arthritis. The tolerability profiles of the two formulations were similar in terms of the types of complaints reported. It is concluded that enteric-coated naproxen is an efficacious and well-tolerated formulation for the treatment of osteoarthritis and rheumatoid arthritis. |
| Databáze: | OpenAIRE |
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