The relationship between follicle-stimulating hormone dose and level and its relevance for ovulation induction with adjuvant gonadotropin-releasing hormone-agonist treatment
| Autor: | Fedde Scheele, Erik Schoute, Maartje van der Meer, Joop Schoemaker, Peter G.A. Hompes |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty medicine.drug_class medicine.medical_treatment Differential Threshold Biology Buserelin Follicle-stimulating hormone Ovarian Follicle Gonadotropin-releasing hormone agonist Internal medicine Follicular phase medicine Humans Adjuvants Pharmaceutic Ovulation Detection Dose-Response Relationship Drug Obstetrics and Gynecology Luteinizing Hormone Polycystic ovary Endocrinology Reproductive Medicine Drug Therapy Combination Female Ovulation induction Follicle Stimulating Hormone Gonadotropin Luteinizing hormone Mathematics hormones hormone substitutes and hormone antagonists Polycystic Ovary Syndrome medicine.drug |
| Zdroj: | Fertility and Sterility. 60:620-625 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/s0015-0282(16)56211-6 |
| Popis: | Objective To investigate the effect of a GnRH agonist (GnRH-a) on the FSH threshold level and the relationship between the FSH dose and the FSH level of patients suffering from polycystic ovarian syndrome (PCOS). Design The stimulation with low-dose FSH in PCOS (group 1) was compared with the subsequently performed stimulation with low-dose FSH combined with GnRH-a in another group of patients suffering from the same syndrome (group 2). Setting Specialist Reproductive Endocrine Unit. Patients Suffering from clomiphene citrate-resistant PCOS. Main Outcome Measures The FSH threshold level for ongoing follicular growth and the relationship between dose and level of FSH. Results In 15 patients in group 1 and in 13 patients in group 2, respectively, 39 and 32 stimulation cycles were performed. Below and above threshold values of FSH of group 1 and 2 did not differ significantly. For the equation stable level of FSH (Y mIU/mL) = A X infusion rate of FSH (X IU/24 h) + basal level of FSH (B mIU/mL), the median A of group 1 was 0.027 and A of group 2 was 0.055 (significant difference). Conclusions In PCOS, a change of the FSH threshold level for ongoing follicular growth induced by the GnRH-a could neither be proven nor ruled out. The use of a GnRH-a resulted in larger FSH level increases per IU/24 h of FSH administered and might therefore interfere with the effect of low-dose FSH treatment. |
| Databáze: | OpenAIRE |
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