Prognostic Value of Aortoiliac Calcification Score in Kidney Transplantation Recipients

Autor: Bertrand Chavent, Ambroise Duprey, Jean-Noël Albertini, Claire Boutet, Nicolas Maillard, Jean-Pierre Favre
Rok vydání: 2017
Předmět:
Male
medicine.medical_specialty
Time Factors
Computed Tomography Angiography
Population
Aortic Diseases
030232 urology & nephrology
Renal function
Kaplan-Meier Estimate
030204 cardiovascular system & hematology
Iliac Artery
Severity of Illness Index
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Risk Factors
Internal medicine
Severity of illness
medicine
Humans
Vascular Calcification
education
Kidney transplantation
Aged
Retrospective Studies
Computed tomography angiography
education.field_of_study
medicine.diagnostic_test
business.industry
Graft Survival
Retrospective cohort study
General Medicine
Middle Aged
medicine.disease
Kidney Transplantation
Treatment Outcome
ROC Curve
Area Under Curve
Predictive value of tests
Cardiology
Female
Surgery
Radiology
Cardiology and Cardiovascular Medicine
business
Calcification
Zdroj: Annals of Vascular Surgery. 44:245-252
ISSN: 0890-5096
DOI: 10.1016/j.avsg.2017.03.180
Popis: Background Kidney recipients are increasingly older with arterial disease and extended arterial calcifications. In a kidney transplantation population, the prognosis value of aortic and iliac calcifications remains poorly explored. We aimed to assess the impact of pretransplantation aortoiliac vascular calcifications on patients, grafts survival, and cardiovascular events. Methods This retrospective study included kidney transplantation patients from 2006 to 2012 for whom we had available presurgery abdominal computed tomography results (n = 100). We designed a score to quantify aortoiliac calcifications. Primary end points were patient and graft survival. Secondary end points were renal function and cardiovascular morbidity. Predictive performances of calcification score were assessed using area under receiver-operating characteristic curves. Patients were classified in quartiles depending on global calcium score value. Results The cumulated rate of death and graft loss was 13% with no significant differences for survival between quartiles. No significant difference was observed in renal function (P = 0.4). Seventeen cardiovascular events were registered with a significant correlation between calcium score elevation and need of cardiovascular surgery during the follow-up (P = 0.01). Global calcium score had a predictive value of 74.5% (95% confidence interval 0.62–0.87) with 71% sensitivity and 73% specificity. Conclusions Aortoiliac calcifications do not decrease patient and graft survival. High calcium score predict cardiovascular events and procedures during the follow-up.
Databáze: OpenAIRE
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