Characteristics and Antioxidant Activities of Silymarin Nanoparticles
| Autor: | Liang Tzung Lin, Tzu Hui Wu, Chun Ching Lin, Wen Chan Hsu, Feng-Lin Yen, Lean-Teik Ng |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Antioxidant
Materials science Superoxide DPPH medicine.medical_treatment Biomedical Engineering Nanoparticle Bioengineering General Chemistry Condensed Matter Physics Antioxidants Bioavailability chemistry.chemical_compound Microscopy Electron Transmission Solubility chemistry Spectroscopy Fourier Transform Infrared medicine Nanoparticles General Materials Science Particle size Dissolution Silymarin Nuclear chemistry |
| Zdroj: | Journal of Nanoscience and Nanotechnology. 12:2022-2027 |
| ISSN: | 1533-4880 |
| DOI: | 10.1166/jnn.2012.5173 |
| Popis: | Silymarin, a well known hepatoprotective drug, has been routinely used in treating liver disorders. However, its bioavailability and therapeutic efficiency are limited by the poor aqueous solubility. In this study, we used the nanoprecipitation technique to develop a nanoparticles system to improve the solubility of silymarin. The newly developed silymarin nanoparticles were characterized for mean particle size, morphology, intermolecular interaction, crystalline features and dissolution property, as well as assessing for antioxidant activities. Results indicated that a drastic change in the physiochemical properties of silymarin was noted in the form of nanoparticles, as displayed by the extremely small particle size (46.1 +/- 1.73 nm), the formation of intermolecular hydrogen bonding between silymarin and matrix of nanoparticles, and the rendering of amorphous state. These phenomena have contributed to the enhanced dissolution property of silymarin nanoparticles, as well as a greater potency in DPPH radical scavenging, anti-superoxide anion formation, and superoxide anion scavenging activities than the crude silymarin. The present study concludes that silymarin nanoparticles have an improved physicochemical property as demonstrated by an increased solubility and enhanced antioxidant activities. |
| Databáze: | OpenAIRE |
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