Ginseng and ginkgo biloba effects on\ud cognition as modulated by cardiovascular\ud reactivity: a randomised trial
| Autor: | Luca Aquili, Mariyam Muslima, Derek Ong Lai Teik, Xiao Shiang Lee, Chu Jian Lim, Chia Mei Low |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Hydrocortisone Vision lcsh:Medicine Social Sciences Blood Pressure Cardiovascular System Vascular Medicine Biochemistry law.invention Ginseng 0302 clinical medicine Cognition Randomized controlled trial law Heart Rate Medicine and Health Sciences Psychology Lipid Hormones lcsh:Science Multidisciplinary Cross-Over Studies biology Ginkgo biloba 05 social sciences Memory Short-Term Cardiovascular Diseases Cardiology Female Sensory Perception Research Article Adult medicine.medical_specialty Cognitive Neuroscience Panax Psychological Stress Placebo 050105 experimental psychology 03 medical and health sciences Young Adult Double-Blind Method Internal medicine Mental Health and Psychiatry medicine Reaction Time Humans 0501 psychology and cognitive sciences Effects of sleep deprivation on cognitive performance Steroid Hormones business.industry Plant Extracts lcsh:R Cognitive Psychology Biology and Life Sciences biology.organism_classification Crossover study Hormones Blood pressure Cognitive Science lcsh:Q business 030217 neurology & neurosurgery Stroop effect Neuroscience |
| Zdroj: | PLoS ONE PLoS ONE, Vol 11, Iss 3, p e0150447 (2016) |
| ISSN: | 0238-6852 1932-6203 |
| Popis: | Background There is some evidence to suggest that ginseng and Ginkgo biloba can improve cognitive performance, however, very little is known about the mechanisms associated with such improvement. Here, we tested whether cardiovascular reactivity to a task is associated with cognitive improvement. Methodology/Principal findings Using a double-blind, placebo controlled, crossover design, participants (N = 24) received two doses of Panax Ginseng (500, 1000 mg) or Ginkgo Biloba (120, 240 mg) (N = 24), and underwent a series of cognitive tests while systolic, diastolic, and heart rate readings were taken. Ginkgo Biloba improved aspects of executive functioning (Stroop and Berg tasks) in females but not in males. Ginseng had no effect on cognition. Ginkgo biloba in females reversed the initial (i.e. placebo) increase in cardiovascular reactivity (systolic and diastolic readings increased compared to baseline) to cognitive tasks. This effect (reversal) was most notable after those tasks (Stroop and Iowa) that elicited the greatest cardiovascular reactivity during placebo. In males, although ginkgo also decreased cardiovascular readings, it did so from an initial (placebo) blunted response (i.e. decrease or no change from baseline) to cognitive tasks. Ginseng, on the contrary, increased cardiovascular readings compared to placebo. Conclusions/Significance These results suggest that cardiovascular reactivity may be a mechanism by which ginkgo but not ginseng, in females is associated with certain forms of cognitive improvement. Trial Registration ClinicalTrials.gov NCT02386852 |
| Databáze: | OpenAIRE |
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