Clinical experiences with Ro 15-1788 (Anexate) in benzodiazepine and mixed-drug overdoses
| Autor: | S. Peruzzi, L. Caramelli, Fabrizio Ledda, Emanuela Masini, M. Baraitini, Flavio Moroni, Roberto Fantozzi, A. M. Zorn, P. F. Mannaioni, Primo Botti |
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| Rok vydání: | 1988 |
| Předmět: |
Adult
Flumazenil Male medicine.drug_class Benzodiazepine overdose Antidepressive Agents Tricyclic Emergency Nursing Drug overdose Phenothiazines medicine Humans Depression (differential diagnoses) Aged Aged 80 and over Benzodiazepine business.industry Poisoning Middle Aged medicine.disease Anti-Anxiety Agents Anesthesia Injections Intravenous Emergency Medicine Anxiety Female medicine.symptom Cardiology and Cardiovascular Medicine business Antipsychotic Agents medicine.drug |
| Zdroj: | Resuscitation. 16:S79-S82 |
| ISSN: | 0300-9572 |
| DOI: | 10.1016/0300-9572(88)90009-3 |
| Popis: | Benzodiazepine overdose is the most common of admission to the Toxicological Unit of the University of Florence. The aim of this study has been to evaluate the efficiency of Ro 15-1788 in benzodiazepine and mixed drug overdoses. The administration of Ro 15-1788 was followed by a quick reversal of central nervous system depression and was more effective in benzodiazepine overdoses than in mixed drug overdoses. The dose was titrated individually and the range 2–10 mg was effective according to the conditions of the patient. In some cases, the comatose state relapsed; further administration of Ro 15-1788 again promptly reversed the condition. On awakening, two patients displayed anxiety and restlessness. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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