Potentiation by amino acid of the therapeutic effect of highly purified vitamin B2 in mice with lipopolysaccharide-induced shock
| Autor: | Toshio Toyosawa, Mamoru Suzuki, Kohtarou Kodama, Seiichi Araki |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Vitamin
Lipopolysaccharides Male Time Factors medicine.medical_treatment Sodium Riboflavin chemistry.chemical_element Pharmacology chemistry.chemical_compound Mice Japan Valine Escherichia coli Medicine Animals Lactic Acid Infusions Intravenous Saline chemistry.chemical_classification Mice Inbred ICR business.industry Interleukin-6 Lethal dose Therapeutic effect Drug Synergism Shock Septic Amino acid Disease Models Animal Glucose chemistry Biochemistry Injections Intravenous Macrophages Peritoneal Drug Therapy Combination business |
| Zdroj: | European journal of pharmacology. 493(1-3) |
| ISSN: | 0014-2999 |
| Popis: | The aim of this experiment was to clarify whether an amino acid supplement could enhance the therapeutic effect of vitamin B2 (riboflavin 5'-sodium phosphate; purity > 97%) in mice with lipopolysaccharide-induced shock. Six hours after injection of a lethal dose of lipopolysaccharide, treatment (6-h i.v. infusion) was commenced. All mice died in the groups treated with saline or aminolevane (an amino acids mixture used to treat hepatopathy); however, the survival rates in the vitamin B2 (10 mg/kg/6 h) and vitamin B2 plus aminolevane groups were 45% (P < 0.05) and 80% (P < 0.05), respectively. Valine (200 mg/kg/6 h) alone had little effect on the survival rate (10%), but the combination of vitamin B2 (10 mg/k/g/6 h) and valine was highly effective (80%, P < 0.05). Clinical trials of vitamin B2 plus amino acids for the treatment of patients with sepsis would appear to be warranted. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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