Lymphoid enhancer-binding factor 1 (LEF-1): a favorable prognostic factor in adult acute myeloid leukemia in Egyptian patients
| Autor: | Raghda El Sayed Abdel Monem Galal, Shaimaa Abdelmalik Pessar, Nashwa El-Khazragy, Doaa G Eissa, Nahela Ahmed Shalaby, Botheina Ahmed Thabet Farweez |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty animal structures lcsh:QH426-470 Granulopoiesis 03 medical and health sciences 0302 clinical medicine Internal medicine LEF-1 expression Favorable outcome medicine Genetics (clinical) Prognostic factor lcsh:R5-920 business.industry Wnt signaling pathway Myeloid leukemia Adult Acute Myeloid Leukemia Adult acute myeloid leukemia medicine.disease lcsh:Genetics Haematopoiesis Leukemia 030104 developmental biology 030220 oncology & carcinogenesis Lymphoid enhancer-binding factor 1 Stem cell lcsh:Medicine (General) business |
| Zdroj: | Egyptian Journal of Medical Human Genetics, Vol 21, Iss 1, Pp 1-11 (2020) |
| ISSN: | 2090-2441 |
| DOI: | 10.1186/s43042-020-00073-5 |
| Popis: | Background Canonical wingless-type (Wnt) signaling is a crucial pathway involved in normal hematopoiesis and the self-renewal process of hematopoietic stem cells. Deregulation of this pathway has been associated with different subtypes of leukemia. Lymphoid enhancer-binding factor 1 (LEF-1) is a major transcription factor of this pathway and plays a pivotal role in lymphoid differentiation and granulopoiesis. High LEF-1 expression has been reported as a prognostic marker in several types of adult hematological malignancies. We aimed to assess the prognostic utility of LEF-1 expression in adult de novo acute myeloid leukemia (AML) Egyptian patients in continuation of our previous work. LEF-1 expression was analyzed by real-time polymerase chain reaction (PCR) in 30 adults with newly diagnosed AML and remeasured at day 28 after induction therapy with the assessment of remission status. Results Patients were classified according to median expression level into high and low LEF-1 expression groups. LEF-1 levels were dramatically decreased following successful induction therapy. Also, high LEF-1 expression patients had a better response to therapy with better overall survival. ROC curve analysis of LEF-1 expression yielded a cutoff value of < 10.11 log10 (sensitivity of 90.48% and specificity of 100%) for predicting poor outcome. Univariate logistic regression analysis showed that for every log10 increase in the LEF-1 expression level, the chance of the patient to achieve hematological remission was increased by 2.29 folds. Conclusion Our study showed preliminary results that overexpression of LEF-1 is a favorable prognostic factor in newly diagnosed adult AML patients. The prognostic value of LEF-1 could suggest its utility for further risk classifications of AML and potentiality for being a target for therapy. |
| Databáze: | OpenAIRE |
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