Copper-Catalyzed Enantioselective 1,4-Protosilylation of Alkynyl-substituted Enones to Synthesize the Highly Diastereomeric Chiral Homoallenylsilanes

Autor:	Qi Li, Zi-Lu Wang, Huan-Xuan Lu, Yun-He Xu
Rok vydání:	2022
Předmět:	Organic Chemistry Physical and Theoretical Chemistry Biochemistry
Zdroj:	Organic Letters. 24:2832-2836
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.2c00739
Popis:	A copper-catalyzed 1,4-protosilylation of α-alkynyl-enones to form the functionalized chiral homoallenylsilanes was developed. In the presence of a chiral monopyridine oxazoline ligand, a variety of trisubstituted allene derivatives bearing a contiguous stereogenic center and axis were prepared in good yields with excellent enantioselectivities and diastereoselectivities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f578fa7bf1b683230fbff77fa067f3 https://doi.org/10.1021/acs.orglett.2c00739 Zobrazit plný text záznamu