Nickel sensitivity in patients with gastroesophageal reflux disease
| Autor: | Nurşad Aslan, Emel Erdal, Mesut Sezikli |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Disease Dermatitis Contact Toxicology Gastroenterology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Nickel Internal medicine medicine Humans Outpatient clinic In patient business.industry Reflux Patch test General Medicine Middle Aged Patch Tests Nickel sensitivity medicine.disease Gastroesophageal Reflux GERD Female 030211 gastroenterology & hepatology business Contact dermatitis |
| Zdroj: | Cutaneous and Ocular Toxicology. 36:347-350 |
| ISSN: | 1556-9535 1556-9527 |
| Popis: | Various foods play important role in the pathogenesis of gastroesophageal reflux disease (GERD). These foods are shown to increase gastroesophageal reflux symptoms via various mechanisms and majority of these foods also contain nickel. The purpose of this study is to evaluate the relationship between Nickel sensitivity and GERD.Fifty-four patients diagnosed with GERD and 50 healthy volunteers who were admitted to our gastroenterology outpatient clinic were took part in the study. European standard patch test series, nickel-containing test units and corticosteroids were applied to the patient body; upper back. Evaluation was performed according to the scheme of the International Contact Dermatitis Research Group (ICDRG). The positive and negative reactions were recorded at the hours of 48, 72 and 96. Following the test implementations, 7 days later, the tests were reevaluated for late reactions. Statistics package for Social Sciences (SPSS) 17 package program was used for statistical evaluation and results of tests were compared between groups with the Chi-squared test. p 0.05 was considered statistically significant.Individuals in both groups were statistically similar in terms of age and gender. Nickel sensitivity was found to be positive in 48.2 and %22 of the GERD patients and control group, respectively. Difference between groups was statistically significant (p = 0.008).Nickel sensitivity was significantly higher in GERD patients compared to the control group. In addition to imbalance between defensive and aggressive forces of the esophagus, there seems to be an association between nickel sensitivity and GERD. |
| Databáze: | OpenAIRE |
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