Gene expression profiles and microsatellite instability in uterine corpus endometrioid adenocarcinoma
| Autor: | Masaru Sakamoto, Yasuko Koyamatsu, Masatoshi Yokoyama, Yoshifumi Nakao, Tetsuya Muroya, Tsuyoshi Iwasaka, Kiyohiko Miyake, Kokichi Sugano |
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| Rok vydání: | 2010 |
| Předmět: |
Microarray
medicine.disease_cause Polymerase Chain Reaction law.invention law medicine Biomarkers Tumor Humans Vimentin Gene Polymerase chain reaction Oligonucleotide Array Sequence Analysis Genetics Chi-Square Distribution business.industry Gene Expression Profiling Obstetrics and Gynecology Cancer Microsatellite instability medicine.disease Immunohistochemistry Gene expression profiling Gene Expression Regulation Neoplastic Receptors Estrogen Uterine Neoplasms Microsatellite Female Microsatellite Instability business Carcinogenesis Receptors Progesterone Carcinoma Endometrioid |
| Zdroj: | The journal of obstetrics and gynaecology research. 36(2) |
| ISSN: | 1447-0756 |
| Popis: | Aim: We examined corpus cancer to identify whether there are distinctive patterns of global gene expression and microsatellite instability, and to gain molecular understanding of its carcinogenesis and progression. Methods: Thirty endometrioid corpus cancer tissue samples (21 of G1 and nine of G2/3) were analyzed by cDNA microarray based on 637 cancer-associated genes and by a polymerase chain reaction method for microsatellite instability. Result: Of the 30 cases, 10 (33%) were recognized as having microsatellite instability. In all cases, four genes were overexpressed and five genes were underexpressed. There were six microsatellite instability-specific overexpressed or high-frequency genes and 15 underexpressed or low-frequency genes. Furthermore, we identified several genes by grade analysis. Conclusions: These results may be useful resources for the development of diagnostic assays, prognostic factors, or therapeutic targets for corpus endometrioid cancer. |
| Databáze: | OpenAIRE |
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