Low Circulating Levels of GR, FKBP5, and SGK1 in Medicated Patients With Depression Are Not Altered by Electroconvulsive Therapy
| Autor: | Lena Poelz, Declan M. McLoughlin, Karen M. Ryan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Neuroscience (miscellaneous) Protein Serine-Threonine Kinases behavioral disciplines and activities Immediate-Early Proteins Tacrolimus Binding Proteins 03 medical and health sciences Receptors Glucocorticoid 0302 clinical medicine Electroconvulsive therapy Rating scale Internal medicine medicine Humans RNA Messenger Electroconvulsive Therapy Depression (differential diagnoses) Aged Whole blood Psychiatric Status Rating Scales Depressive Disorder Major business.industry Middle Aged 030227 psychiatry Peripheral Affect Psychiatry and Mental health Treatment Outcome Endocrinology SGK1 Female FKBP5 business Biomarkers 030217 neurology & neurosurgery Glucocorticoid medicine.drug |
| Zdroj: | The Journal of ECT. 36:137-143 |
| ISSN: | 1533-4112 1095-0680 |
| DOI: | 10.1097/yct.0000000000000633 |
| Popis: | Hypothalamic-pituitary-adrenal axis dysregulation is frequently observed in patients with depression, with increased levels of the glucocorticoid (GC) cortisol commonly reported. Hypothalamic-pituitary-adrenal axis dysregulation may be a consequence of impaired feedback inhibition due to GC receptor (GR) impairments or dysfunction, termed "glucocorticoid resistance." Here, our objective was to assess mRNA levels of GC-related markers (GR, FKBP5, serum glucocorticoid kinase 1 [SGK1]) in patients with depression versus controls and in patient samples after electroconvulsive therapy (ECT). We also examined the relationship between these GC-related markers and 24-item Hamilton Depression Rating Scale (HAM-D24) scores to assess the utility of using them as biological markers for depression or the therapeutic response to ECT.GR, FKBP5, and SGK1 mRNA levels were examined in whole blood samples from 88 medicated patients with depression pre-/post-ECT and 63 controls using quantitative real-time polymerase chain reaction. Exploratory subgroup correlational analyses were performed to determine the relationship between GR, FKBP5, and SGK1 and 24-item Hamilton Depression Rating Scale scores.GR, FKBP5, and SGK1 mRNA levels were significantly lower in medicated patients with depression compared with controls (P0.001, P = 0.03, P0.001, respectively), but ECT did not alter their levels (all P0.05). There was no relationship between GR, FKBP5, or SGK1 and 24-item Hamilton Depression Rating Scale scores.GR, FKBP5, and SGK1 do not seem to be involved in the peripheral molecular response to ECT and do not represent useful biomarkers for predicting the therapeutic response to ECT in a real-world clinical setting. |
| Databáze: | OpenAIRE |
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