Haemodynamic and Hormonal Responses to Cardiac Pacing in Humans: Influence of Different Stimulation Sequences and Rates
| Autor: | Anders Edlund, H. Berglund, Hans Vallin, Elvar Theodorsson |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Cardiac Catheterization medicine.medical_specialty Vasopressin Epinephrine Atrial Pressure Blood Pressure Atrial Function Right Norepinephrine Atrial natriuretic peptide Internal medicine Heart rate medicine Humans Pulmonary Wedge Pressure cardiovascular diseases Cardiac Output Pulmonary wedge pressure Chemistry Low pressure receptor zones Cardiac Pacing Artificial Central venous pressure Stroke Volume General Medicine Arginine Vasopressin medicine.anatomical_structure Endocrinology cardiovascular system Cardiology Vascular resistance Female Vascular Resistance Adrenergic alpha-Agonists Atrial Natriuretic Factor |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1470-8736 0143-5221 |
| DOI: | 10.1042/cs0880165 |
| Popis: | 1. To examine the effects of rate and pressure on release of vasoactive hormones, 10 healthy subjects were examined. 2. A standardized pacing protocol was used to achieve different haemodynamic responses at two predetermined heart rates. Haemodynamic variables, and plasma concentrations of atrial natriuretic peptide, arginine vasopressin, adrenaline and noradrenaline were measured. 3. Right atrioventricular pacing at a rate of 150 impulses/min resulted in disparate responses in right atrial pressure (slight decrease) and pulmonary capillary wedge pressure (increase). Change in arterial plasma concentration of atrial natriuretic peptide correlated to change in pulmonary capillary wedge pressure, and change in arterial plasma concentration of noradrenaline correlated to change in total systemic vascular resistance, whereas concentrations of adrenaline and arginine vasopressin did not alter significantly during the stimulation periods. A significant influence of rate in addition to the pressure related influence on plasma concentration of atrial natriuretic peptide was found. In contrast, an increase in rate in the absence of an increase in atrial pressures did not raise the plasma concentration of atrial natriuretic peptide. There was no significant relationship between change in atrial natriuretic peptide and noradrenaline. 4. These data support the concept of a rate dependence of atrial natriuretic peptide release in man. Increased atrial pressure and thus presumed atrial stretch seems to be a prerequisite for increased plasma concentration of atrial natriuretic peptide. In addition, these results highlight the importance of monitoring both left and right atrial pressure in clinical investigations assessing modulation of atrial natriuretic peptide release. |
| Databáze: | OpenAIRE |
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