Determinants of plasma platelet-activating factor acetylhydrolase: heritability and relationship to plasma lipoproteins
| Autor: | Rudy Guerra, Biren Zhao, Jonathan Cohen, Vincent Mooser, John M. Johnston, Diana M. Stafforini |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Cholesterol Family aggregation Cell Biology Familial hypercholesterolemia QD415-436 Heritability respiratory system medicine.disease 1-Alkyl-2-acetylglycerophosphocholine Esterase Biochemistry chemistry.chemical_compound Endocrinology chemistry Low-density lipoprotein Internal medicine Hyperlipidemia medicine lipids (amino acids peptides and proteins) Lovastatin medicine.drug |
| Zdroj: | Journal of Lipid Research, Vol 38, Iss 11, Pp 2281-2288 (1997) |
| ISSN: | 0022-2275 |
| Popis: | Plasma platelet-activating factor acetylhydrolase (PAF-AH) is the enzyme that inactivates PAF (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine). We determined the relative contributions of genetic and environmental factors to variation in plasma PAF-AH activity in 240 individuals from 60 nuclear families. Regression of mean-offspring PAF-AH activity on the mid-parent value indicated that 62% of the variation in plasma PAF-AH activity was heritable. Spousal values were weakly negatively correlated, indicating that familial aggregation of PAF-AH activity is due to genetic rather than to environmental factors. Among normolipidemic individuals, plasma PAF-AH activity was strongly correlated with the plasma concentration of low density lipoprotein cholesterol (LDL-C), and treatment with lovastatin resulted in proportional decreases in plasma PAF-AH activity and LDL-C concentrations. To further elucidate the relationship between PAF-AH and plasma concentrations of LDL, plasma PAF-AH activity was measured in families with well-defined, monogenic disorders of LDL metabolism. Plasma PAF-AH activity cosegregated with plasma LDL-C concentrations in familial hypercholesterolemia, but not in familial hypobetalipoproteinemia. We speculate that the rate of removal of LDL from the circulation may determine the clearance rate of PAF-AH, thereby modulating the activity of PAF-AH in blood. |
| Databáze: | OpenAIRE |
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