Targeting Colorectal Cancer Stem Cells as an Effective Treatment for Colorectal Cancer

Autor: Wen Li, Qin-Lu Lin, Yu Liu, Yi Shi, Da Fu, Yu-Shui Ma
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Cancer Research
Colorectal cancer
medicine.medical_treatment
Antineoplastic Agents
Review
medicine.disease_cause
lcsh:RC254-282
CSC
Metastasis
Targeted therapy
03 medical and health sciences
0302 clinical medicine
Antigens
CD
Cancer stem cell
Biomarkers
Tumor
Tumor Microenvironment
medicine
Animals
Humans
Molecular Targeted Therapy
030304 developmental biology
0303 health sciences
drug resistance
biology
CCSCs
business.industry
CD44
LGR5
Cell Differentiation
targeted therapy
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
CRC
Gene Expression Regulation
Neoplastic
Phenotype
Treatment Outcome
Oncology
030220 oncology & carcinogenesis
Neoplastic Stem Cells
Cancer research
biology.protein
Stem cell
Colorectal Neoplasms
business
Carcinogenesis
Signal Transduction
Zdroj: Technology in Cancer Research & Treatment, Vol 19 (2020)
Technology in Cancer Research & Treatment
ISSN: 1533-0338
Popis: As one of the common cancers that threaten human life, the recurrence and metastasis of colorectal cancer seriously affect the prognosis of patients. Although new drugs and comprehensive treatments have been adopted, the current treatment effect on this tumor, especially in advanced colorectal cancer, is still not satisfactory. More and more evidence shows that tumors are likely to be a stem cell disease. In recent years, the rise of cancer stem cell theory has provided a new way for cancer treatment. Studies have found that a small number of special cells in colorectal cancer tissues that induce tumorigenesis, proliferation, and promote tumor migration and metastasis, namely, colorectal cancer stem cells. Colorectal cancer stem cells are defined with a group of cell-surface markers, such as CD44, CD133, CD24, epithelial cell adhesion factor molecule, LGR5, and acetaldehyde dehydrogenase. They are highly tumorigenic, aggressive, and chemoresistant and thus are critical in the metastasis and recurrence of colorectal cancer. Therefore, targeting colorectal cancer stem cells may become an important research direction for the future cure of colorectal cancer.
Databáze: OpenAIRE
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