Association between Subcortical Lesions and Behavioral and Psychological Symptoms in Patients with Alzheimer's Disease
| Autor: | Lena Bronge, Agmall Sarwari, Carina Wattmo, Lars-Olof Wahlund, Yi Zhang, Sebastian Palmqvist, Katarina Nägga |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Neurology Hallucinations Cognitive Neuroscience Behavioral Symptoms Disease Basal Ganglia Delusions Basal Ganglia Diseases Alzheimer Disease Parietal Lobe medicine Humans Dementia In patient Longitudinal Studies Association (psychology) Psychiatry Subcortical lesions Aged Aged 80 and over Geriatrics Depression medicine.disease Frontal Lobe Radiography Psychiatry and Mental health Female Geriatrics and Gerontology Psychology |
| Zdroj: | Dementia and Geriatric Cognitive Disorders; 32(6), pp 417-423 (2011) |
| ISSN: | 1420-8008 |
| Popis: | Background/Aims: The most devastating features of Alz-heimer's disease (AD) are often the behavioral and psychological symptoms in dementia (BPSD). There is controversy as to whether subcortical lesions contribute to BPSD. The aim of this study was to examine the relationship between BPSD and subcortical lesions (white-matter lesions and lacunes) in AD. Methods: CT or MRI from 259 patients with mild-to-moderate AD were assessed with the Age-Related White Matter Changes scale. Linear measures of global and temporal atrophy and Mini-Mental State Examination scores were used to adjust for AD pathology and disease severity in logistic regression models with the BPSD items delusions, hallucinations, agitation, depression, anxiety, apathy and irritability. Results: Lacunes in the left basal ganglia were asso-ciated with delusions (OR 2.57, 95% CI 1.21-5.48) and hallucinations (OR 3.33, 95% CI 1.38-8.01) and lacunes in the right basal ganglia were associated with depression (OR 2.13, 95% CI 1.01-4.51). Conclusion: Lacunes in the basal ganglia resulted in a 2- to 3-fold increased risk of delusions, hallucinations and depression, when adjusting for cognition and atrophy. This suggests that basal ganglia lesions can contribute to BPSD in patients with AD, independently of the AD process. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|