Secretin: A Pleiotrophic Hormone
| Autor: | Billy K. C. Chow, Jessica Y. S. Chu, Wing-Ho Yung |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Secretin receptor family Secretin family Biology digestive system General Biochemistry Genetics and Molecular Biology Receptors G-Protein-Coupled Receptors Gastrointestinal Hormone Secretin fluids and secretions History and Philosophy of Science Internal medicine medicine Animals Humans Disease Receptor Gastrointestinal tract Gastrointestinal Physiology General Neuroscience digestive system diseases Endocrinology medicine.anatomical_structure Pancreas hormones hormone substitutes and hormone antagonists Signal Transduction Hormone |
| Zdroj: | Annals of the New York Academy of Sciences. 1070:27-50 |
| ISSN: | 0077-8923 |
| DOI: | 10.1196/annals.1317.013 |
| Popis: | Secretin holds a unique place in the history of endocrinology and gastrointestinal physiology, as it is the first peptide designated as a hormone. During the last century since its first discovery, the hormonal effects of secretin in the gastrointestinal tract were extensively studied, and its principal role in the periphery was found to stimulate exocrine secretion from the pancreas. Recently, a functional role of secretin in the brain has also been substantiated, with evidence suggesting a possible role of secretin in embryonic brain development. Given that secretin and its receptors are widely expressed in multiple tissues, this peptide should therefore exhibit pleiotrophic functions throughout the body. The present article reviews the current knowledge on the central and peripheral effects of secretin as well as its therapeutic uses. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |