Prevalence of peripheral arterial disease in patients at non-high cardiovascular risk. Rationale and design of the PANDORA study
Autor: | Beat Kindler, Serge Kownator, Jean-Claude Wautrecht, Claudio Borghi, Stefanus Eliza Kranendonk, Christos C.P. Carvounis, Claudio Cimminiello, Mario Mangrella |
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Přispěvatelé: | Cimminiello C, Borghi C, Kownator S, Wautrecht JC, Cavounis CP, Kranendonk SE, Kindler B, Mangrella M |
Rok vydání: | 2010 |
Předmět: |
lcsh:Diseases of the circulatory (Cardiovascular) system
medicine.medical_specialty Cardiologie et circulation Population Disease Asymptomatic Coronary artery disease Study Protocol Peripheral Arterial Disease Risk Factors Surveys and Questionnaires Diabetes mellitus Internal medicine Epidemiology Prevalence medicine Humans Ankle Brachial Index Myocardial infarction education education.field_of_study business.industry American Heart Association medicine.disease United States Europe body regions Blood pressure lcsh:RC666-701 Epidemiologic Research Design Practice Guidelines as Topic Physical therapy medicine.symptom Cardiology and Cardiovascular Medicine business Biomarkers |
Zdroj: | BMC cardiovascular disorders, 10 BMC Cardiovascular Disorders BMC Cardiovascular Disorders, Vol 10, Iss 1, p 35 (2010) |
ISSN: | 1471-2261 |
Popis: | Background: Lower extremity peripheral arterial disease (PAD) is a marker of widespread atherosclerosis. Individuals with PAD, most of whom do not show typical PAD symptoms ('asymptomatic' patients), are at increased risk of cardiovascular ischaemic events. American College of Cardiology/American Heart Association guidelines recommend that individuals with asymptomatic lower extremity PAD should be identified by measurement of ankle-brachial index (ABI). However, despite its associated risk, PAD remains under-recognised by clinicians and the general population and office-based ABI detection is still poorly-known and under-used in clinical practice. The Prevalence of peripheral Arterial disease in patients with a non-high cardiovascular disease risk, with No overt vascular Diseases nOR diAbetes mellitus (PANDORA) study has a primary aim of assessing the prevalence of lower extremity PAD through ABI measurement, in patients at non-high cardiovascular risk, with no overt cardiovascular diseases (including symptomatic PAD), or diabetes mellitus. Secondary objectives include documenting the prevalence and treatment of cardiovascular risk factors and the characteristics of both patients and physicians as possible determinants for PAD under-diagnosis.Methods/Design: PANDORA is a non-interventional, cross-sectional, pan-European study. It includes approximately 1,000 primary care participating sites, across six European countries (Belgium, France, Greece, Italy, The Netherlands, Switzerland). Investigator and patient questionnaires will be used to collect both right and left ABI values at rest, presence of cardiovascular disease risk factors, current pharmacological treatment, and determinants for PAD under-diagnosis.Discussion: The PANDORA study will provide important data to estimate the prevalence of asymptomatic PAD in a population otherwise classified at low or intermediate risk on the basis of current risk scores in a primary care setting.Trial registration number: Clinical Trials.gov Identifier: NCT00689377. © 2010 Cimminiello et al; licensee BioMed Central Ltd. SCOPUS: ar.j info:eu-repo/semantics/published |
Databáze: | OpenAIRE |
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