Longitudinal increase in the volume of white matter hyperintensities in late-onset depression
| Autor: | Judith Saxton, Carolyn C. Meltzer, Charles F. Reynolds, Edythe M. Halligan, Robert D. Nebes, Steven T. DeKosky, Fernando E. Boada, Melanie B. Fukui |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Trail Making Test Audiology behavioral disciplines and activities medicine Humans Verbal fluency test Longitudinal Studies Age of Onset Psychiatry Depression (differential diagnoses) Aged Cerebral Cortex First episode Depressive Disorder Magnetic Resonance Imaging Hyperintensity Cerebrovascular Disorders Psychiatry and Mental health Case-Control Studies Geriatrics and Gerontology Age of onset Cognition Disorders Mental Status Schedule Psychology Stroop effect Executive dysfunction |
| Zdroj: | International Journal of Geriatric Psychiatry. 17:526-530 |
| ISSN: | 1099-1166 0885-6230 |
| DOI: | 10.1002/gps.635 |
| Popis: | Background Cerebrovascular disease is thought to play a role in the pathogenesis of geriatric major depression. One finding supporting such a ‘vascular depression’ is the increased neuropathology in the form of white matter hyperintensities (WMH) found in patients diagnosed with a late-onset depression. However, at present there is little evidence that a longitudinal increase in WMH burden within an individual is associated with the onset of a late-life depression. Methods This study examined three-year longitudinal change in WMH volume and in cognition in: (a) an older man who developed his first episode of major depression during the study period, and (b) a comparison group of twelve older individuals who remained depression free. All subjects received at baseline and three years later a structural magnetic resonance imaging (MRI) using fast-FLAIR technology. The images were analyzed with semi-automated computerized software to obtain WMH volumes. Subjects also received at both time points the Mini Mental State Exam (MMSE) as well a series of cognitive tasks assessing executive abilities (verbal fluency, Trail Making Test and Stroop test) since executive dysfunction is thought to be characteristic of a vascular depression. Results The individual who became depressed during the followup showed an increase in WMH volume that exceeded the 95% Confidence Intervals (CI) for change in the comparison group. This individual also showed a similar decline on the measures of executive function but not on the MMSE. Conclusions These results are consistent with cerebrovascular disease being a factor in the pathogenesis of late-onset depression (i.e. ‘vascular depression’). Copyright © 2002 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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